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Collaboration Agreements, License Agreement and Revenues - AstraZeneca Agreements - Additional Information 1 (Detail) - USD ($) $ in Thousands		3 Months Ended		6 Months Ended
	Jul. 30, 2013	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022	Dec. 31, 2022
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Total revenue		$ 44,319	$ 29,806	$ 80,480	$ 90,633
Deferred Revenue		7,490		7,490		$ 12,739
Drug product revenue recognized		44,319	29,806	80,480	90,633
Product Revenue, Net [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Total revenue		23,889	23,256	48,049	42,137
Drug product revenue recognized		23,889	23,256	48,049	42,137
Drug Product Revenue, Net [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Total revenue		14,272	1,093	16,381	8,687
Drug product revenue recognized		14,272	1,093	$ 16,381	8,687
AstraZeneca Agreements [Member] | U.S./RoW [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Upfront, non-contingent, non-refundable and time-based payments	$ 1,200,000
Additional consideration based on net sales description				low 20% range
Aggregate consideration received excluding drug product revenue		439,000		$ 439,000
AstraZeneca Agreements [Member] | China [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Upfront, non-contingent, non-refundable and time-based payments	$ 376,700
Aggregate considerations received				77,200
Direct Sales [Member] | Product Revenue, Net [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Total revenue		3,377	3,519	6,165	6,178
Drug product revenue recognized		$ 3,377	$ 3,519	$ 6,165	$ 6,178

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