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Collaboration Agreements, License Agreement and Revenues - Roll-forward of Related Contract Liabilities (Detail)
$ in Thousands
6 Months Ended
Jun. 30, 2023
USD ($)
AstraZeneca Agreements [Member]  
Contract with Customer Liability [Line Items]  
Balance at December 31, 2022 $ (175,646)
Additions (46,428)
Currency Translation and Other 1,971
Recognized as Revenue 41,884
Balance at June 30, 2023 (178,219)
Drug Product Revenue, Net [Member] | Astellas Agreement [Member] | Europe [Member]  
Contract with Customer Liability [Line Items]  
Balance at December 31, 2022 (40,303)
Additions 0
Reclassified to Accrued Liability 23,963
Recognized as Revenue 840
Balance at June 30, 2023 $ (15,500)