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Collaboration Agreements, License Agreement and Revenues - Drug Product Revenue - Additional Information (Detail) - USD ($) $ in Thousands	3 Months Ended				6 Months Ended
	Jun. 30, 2023	Mar. 31, 2023	Jun. 30, 2022	Mar. 31, 2022	Jun. 30, 2023	Jun. 30, 2022	Dec. 31, 2022
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Deferred Revenue	$ 7,490				$ 7,490		$ 12,739
Drug product revenue recognized	44,319		$ 29,806		80,480	$ 90,633
Other long-term liabilities	4,961				4,961		6,440
Astra Zeneca Agreements [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Royalty revenue recognized as drug product revenue					41,884
Drug Product Revenue, Net [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Drug product revenue recognized	14,272		1,093		16,381	8,687
Drug Product Revenue, Net [Member] | Astellas Agreement [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Drug product revenue recognized	14,300				16,400
Drug Product Revenue, Net [Member] | Europe [Member] | Astellas Agreement [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Drug product revenue recognized	463		1,076		840	1,076
Drug Product Revenue, Net [Member] | Europe [Member] | Astellas Europe Agreement [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Drug product revenue recognized					24,000
Accrued liabilities							57,400
Drug Product Revenue, Net [Member] | Europe [Member] | Astellas Europe Agreement [Member] | Royalty Revenue [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Royalty revenue recognized as drug product revenue	500				800
Drug Product Revenue, Net [Member] | Japan [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Drug product revenue recognized	14,400	$ 1,700		$ 9,800
Drug Product Revenue, Net [Member] | Japan [Member] | Astellas Agreement [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Drug product revenue recognized	13,809		$ 17		15,541	$ 7,611
Accounts payable	4,600				4,600
Accrued liabilities	1,400				1,400		$ 6,500
Other long-term liabilities	600				600
Drug Product Revenue, Net [Member] | API Shipment [Member] | Japan [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Drug product revenue recognized	600			$ 2,200
Bulk Drug Product [Member] | Astra Zeneca Agreements [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Drug product revenue recognized					11,200
Bulk Drug Product [Member] | Europe [Member] | Astellas Europe Agreement [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Accrued liabilities	$ 23,800				$ 23,800

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