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Collaboration Agreements, License Agreement and Revenues - AstraZeneca Agreements - Additional Information 1 (Detail) - USD ($) $ in Thousands |  | 3 Months Ended | 9 Months Ended |  |
--- | --- | --- | --- | --- | ---
Jul. 30, 2013 | Sep. 30, 2023 | Sep. 30, 2022 | Sep. 30, 2023 | Sep. 30, 2022 | Sep. 18, 2023 | Dec. 31, 2022
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Total revenue |  | $ 40,134 | $ 15,735 | $ 120,614 | $ 106,367 |  |
Deferred Revenue |  | 7,325 |  | 7,325 |  |  | $ 12,739
Drug product revenue recognized |  | 40,134 | 15,735 | 120,614 | 106,367 |  |
Product Revenue, Net [Member] |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Total revenue |  | 29,390 | 17,359 | 77,439 | 59,495 |  |
Drug product revenue recognized |  | 29,390 | 17,359 | 77,439 | 59,495 |  |
Drug Product Revenue, Net [Member] |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Total revenue |  | 1,320 | (4,077) | 17,701 | 4,610 |  |
Drug product revenue recognized |  | 1,320 | (4,077) | 17,701 | 4,610 |  |
AstraZeneca Agreements [Member] |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Recognized as Revenue |  |  |  | $ 68,347 |  |  |
AstraZeneca Agreements [Member] | U.S./RoW [Member] |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Upfront, non-contingent, non-refundable and time-based payments | $ 1,200,000 |  |  |  |  |  |
Additional consideration based on net sales description |  |  |  | low 20% range |  |  |
Aggregate consideration received excluding drug product revenue |  | 439,000 |  | $ 439,000 |  |  |
AstraZeneca Agreements [Member] | China [Member] |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Upfront, non-contingent, non-refundable and time-based payments | $ 376,700 |  |  |  |  |  |
Aggregate considerations received |  |  |  | 77,200 |  |  |
Transaction price and allocated to performance obligations |  |  |  |  |  | $ 4,000 |
Recognized as Revenue |  | 3,500 |  |  |  |  |
Contract asset |  | 4,000 |  | 4,000 |  |  |
Direct Sales [Member] | Product Revenue, Net [Member] |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Total revenue |  | 2,927 | 2,445 | 9,092 | 8,622 |  |
Drug product revenue recognized |  | $ 2,927 | $ 2,445 | $ 9,092 | $ 8,622 |  |

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