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Collaboration Agreements, License Agreement and Revenues - Drug Product Revenue - Additional Information (Detail) - USD ($) $ in Thousands | 3 Months Ended | 9 Months Ended |
--- | --- | --- | ---
Sep. 30, 2023 | Jun. 30, 2023 | Mar. 31, 2023 | Sep. 30, 2022 | Mar. 31, 2022 | Sep. 30, 2023 | Sep. 30, 2022 | Dec. 31, 2022
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |
Deferred Revenue | $ 7,325 |  |  |  |  | $ 7,325 |  | $ 12,739
Drug product revenue recognized | 40,134 |  |  | $ 15,735 |  | 120,614 | $ 106,367 |
Other long-term liabilities | 4,255 |  |  |  |  | 4,255 |  | 6,440
Astra Zeneca Agreements [Member] |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |
Royalty revenue recognized as drug product revenue |  |  |  |  |  | 68,347 |  |
Drug Product Revenue, Net [Member] |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |
Drug product revenue recognized | 1,320 |  |  | (4,077) |  | 17,701 | 4,610 |
Drug Product Revenue, Net [Member] | Astellas Agreement [Member] |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |
Drug product revenue recognized | 1,300 |  |  |  |  | 17,700 |  |
Drug Product Revenue, Net [Member] | Europe [Member] | Astellas Agreement [Member] |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |
Drug product revenue recognized | 625 |  |  | 236 |  | 1,465 | 1,313 |
Drug Product Revenue, Net [Member] | Europe [Member] | Astellas Europe Agreement [Member] |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |
Drug product revenue recognized |  |  |  |  |  | 28,700 |  |
Accrued liabilities |  |  |  |  |  |  |  | 57,400
Drug Product Revenue, Net [Member] | Europe [Member] | Astellas Europe Agreement [Member] | Royalty Revenue [Member] |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |
Royalty revenue recognized as drug product revenue | 600 |  |  |  |  | 1,500 |  |
Drug Product Revenue, Net [Member] | Japan [Member] |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |
Drug product revenue recognized |  | $ 14,400 | $ 1,700 |  | $ 9,800 |  |  |
Drug Product Revenue, Net [Member] | Japan [Member] | Astellas Agreement [Member] |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |
Drug product revenue recognized | 695 |  |  | (4,313) |  | 16,236 | $ 3,297 |
Accrued liabilities | 600 |  |  |  |  | 600 |  | $ 6,500
Other long-term liabilities | 700 |  |  |  |  | 700 |  |
Drug Product Revenue, Net [Member] | API Shipment [Member] | Japan [Member] |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |
Drug product revenue recognized | 700 | $ 600 |  | $ 4,300 | $ 2,200 |  |  |
Bulk Drug Product [Member] | Astra Zeneca Agreements [Member] |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |
Drug product revenue recognized |  |  |  |  |  | 11,200 |  |
Bulk Drug Product [Member] | Europe [Member] | Astellas Europe Agreement [Member] |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |
Accrued liabilities | $ 28,600 |  |  |  |  | $ 28,600 |  |

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