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Collaboration Agreements, License Agreement and Revenues - Product Revenue, Net - Additional Information 1 (Detail) - USD ($) $ in Thousands | 3 Months Ended | 9 Months Ended |
--- | --- | --- | ---
Sep. 30, 2023 | Sep. 30, 2022 | Sep. 30, 2023 | Sep. 30, 2022 | Dec. 31, 2022
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |
Total revenue | $ 40,134 | $ 15,735 | $ 120,614 | $ 106,367 |
Constrained for Future Recognition [Member] |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |
Total revenue | 2,300 |  | 1,100 |  |
Product Revenue, Net [Member] |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |
Total revenue | 29,390 | $ 17,359 | 77,439 | $ 59,495 |
AstraZeneca Agreements [Member] |  |  |  |  |
Contract with Customer, Liability [Abstract] |  |  |  |  |
Deferred Revenue | 177,576 |  | 177,576 |  | $ 175,646
AstraZeneca Agreements [Member] | China [Member] |  |  |  |  |
Contract with Customer, Liability [Abstract] |  |  |  |  |
Deferred Revenue | 28,000 |  | 28,000 |  |
Beijing Falikang Pharmaceutical Co Ltd | Product Revenue, Net [Member] |  |  |  |  |
Contract with Customer, Liability [Abstract] |  |  |  |  |
Reductions to gross accounts receivable | $ 2,500 |  | $ 2,500 |  | $ 500

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