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Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2021
Operating activities |  |  |
Net loss | $ (284,232) | $ (293,654) | $ (290,023)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Depreciation | 9,518 | 10,017 | 10,170
Amortization of finance lease right-of-use assets | 412 | 587 | 4,639
Net accretion of premium and discount on investments | (5,061) | 1,619 | 2,482
Unrealized loss on equity investments | 0 | 0 | 30
Investment income in unconsolidated variable interest entity | (2,638) | (1,573) | (1,007)
Loss (gain) on disposal of property and equipment | 4 | (1) | 233
Stock-based compensation | 50,767 | 65,601 | 71,161
Acquired In-process Research and Development Expenses | 24,636 | 0 | 60,000
Non-cash interest expense related to sale of future revenues | 7,734 | 1,036 | 0
Dividend received from unconsolidated variable interest entity | 2,255 | 0 | 0
Impairment of investment | 1,000 | 0 | 0
Realized loss on sales of available-for-sale securities | 271 | 5 | 0
Changes in operating assets and liabilities: |  |  |
Accounts receivable, net ($6,009, $(1,158) and $(6,803) from related parties) | 3,433 | 765 | 25,180
Inventories | (1,695) | (10,999) | (14,158)
Prepaid expenses and other current assets ($0, $0 and $889 from a related party) | (28,165) | 4,916 | (9,854)
Operating lease right-of-use assets | 11,704 | 10,908 | 4,209
Other assets | 256 | 263 | (4,412)
Accounts payable ($0, $0 and $(1,118) from a related party) | (15,514) | 5,909 | 805
Accrued and other liabilities ($(24,072), $63,882 and $(20) from a related party) | (49,778) | 90,556 | 16,380
Operating lease liabilities, current | 3,820 | (547) | 503
Deferred revenue ($(23,378), $11,211 and $21,549 from related parties) | (28,166) | (4,130) | 57,637
Accrued interest for finance lease liabilities | (11) | 33 | (75)
Operating lease liabilities, non-current | (12,998) | (8,994) | (4,043)
Other long-term liabilities | (2,573) | (18,250) | (12,089)
Net cash used in operating activities | (315,021) | (145,933) | (82,232)
Investing activities |  |  |
Purchases of property and equipment | (2,519) | (3,741) | (5,186)
Payment made for acquired in-process research and development asset | 0 | (35,000) | (25,000)
Proceeds from sale of property and equipment | 0 | 6 | 0
Purchases of available-for-sale securities | (251,830) | (164,023) | (484,144)
Cash acquired from consolidation of Fortis | 656 | 0 | 0
Proceeds from sales of available-for-sale securities | 6,729 | 7,382 | 4,214
Proceeds from maturities of investments | 400,621 | 284,492 | 83,144
Net cash provided by (used in) investing activities | 153,657 | 89,116 | (426,972)
Financing activities |  |  |
Proceeds from senior secured term loan facilities, net of issuance costs | 74,078 | 0 | 0
Cash paid for transaction costs for senior secured term loan facilities | (2,746) | 0 | 0
Repayments of finance lease liabilities | (148) | (135) | (5,489)
Repayments of lease obligations | (336) | (403) | (403)
Cash paid for payroll taxes on restricted stock unit releases | (237) | (5,167) | (7,372)
Proceeds from sale of future revenues, net of issuance costs | 0 | 49,750 | 0
Cash paid for transaction costs related to sale of future revenues | 0 | (1,453) | 0
Proceeds from issuance of common stock under ATM Program, net of commissions | 48,407 | 0 | 0
Proceeds from issuance of common stock under employee stock plans | 3,731 | 4,184 | 12,701
Net cash provided by (used in) financing activities | 122,749 | 46,776 | (563)
Effect of exchange rate change on cash and cash equivalents | (3,397) | (5,482) | 2,597
Net decrease in cash and cash equivalents | (42,012) | (15,523) | (507,170)
Total cash and cash equivalents at beginning of period | 155,700 | 171,223 | 678,393
Total cash and cash equivalents at end of period | 113,688 | 155,700 | 171,223
Supplemental Cash Flow Information [Abstract] |  |  |
Non cash acquisition in Fortis | (22,000) | 0 | 0
Interest payments | 54 | 104 | 94
Balance in accounts payable and accrued liabilities related to purchases of property and equipment | 103 | 428 | 1,009
Balance in accrued liabilities related to issuance costs of secured term loan facilities | 0 | 0 | 35,000
Balance in other receivables related to stock option exercise | 0 | 0 | 165
Conversion of subsidiary's convertible note payable to non-controlling interests | $ 0 | $ 0 | $ 696

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