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Income Taxes - Schedule of Significant Components of Deferred Tax Assets (Detail) - USD ($) $ in Thousands | Dec. 31, 2023 | Dec. 31, 2022
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Components of Deferred Tax Assets and Liabilities [Abstract] |  |
Federal and state net operating loss carryforwards | $ 175,257 | $ 166,708
Tax credit carryforwards | 123,156 | 106,131
Foreign net operating loss carryforwards | 48,396 | 49,990
Capitalized research and development expenses | 81,697 | 45,125
Stock-based compensation | 9,155 | 8,616
Lease obligations | 17,189 | 18,442
Reserves and accruals | 5,475 | 4,929
Deferred revenue | 24,792 | 21,624
Intangible assets | 63,146 | 69,159
Other | 698 | 1,277
Subtotal | 548,961 | 492,001
Less: Valuation allowance | (534,967) | (477,969)
Net deferred tax assets | 13,994 | 14,032
Fixed assets | (10,511) | (13,101)
Non-deductible accrued expenses | (3,483) | (931)
Net deferred tax liabilities | (13,994) | (14,032)
Total net deferred tax assets | $ 0 | $ 0

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