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Collaboration Agreements, License Agreement and Revenues - Transaction Price Related to Consideration Received and Accounts Receivable Allocated to Performance Obligations Deferred Revenue (Detail) - AstraZeneca Agreements [Member] - USD ($) $ in Thousands | Dec. 31, 2023 | Dec. 31, 2022
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Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |
Deferred Revenue | $ 179,851 | $ 175,646
U.S./RoW and China [Member] |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |
Cumulative Revenue | 1,165,393 |
Deferred Revenue | 179,851 |
Total Consideration | 1,345,244 |
U.S./RoW and China [Member] | License Revenue [Member] |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |
Cumulative Revenue | 344,493 |
Deferred Revenue | 0 |
Total Consideration | 344,493 |
U.S./RoW and China [Member] | Co-development, information sharing & committee services [Member] |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |
Cumulative Revenue | 625,111 |
Deferred Revenue | 0 |
Total Consideration | 625,111 |
U.S./RoW and China [Member] | China performance obligation [Member] |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |
Cumulative Revenue | 195,789 |
Deferred Revenue | 179,851 |
Total Consideration | $ 375,640 |

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