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Collaboration Agreements, License Agreement and Revenues - Summary of License Revenue and Development Revenue Recognized under Agreement (Detail) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2021
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |
Total revenue | $ 147,752 | $ 140,734 | $ 235,309
License Revenue [Member] |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |
Total revenue | 9,649 | 22,590 | 116,434
Development Revenue [Member] |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |
Total revenue | 18,401 | 24,189 | 70,275
Astellas Agreement [Member] | License Revenue [Member] | Europe [Member] |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |
Total revenue | 0 | 22,590 | 108,434
Astellas Agreement [Member] | Development Revenue [Member] | Japan [Member] |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |
Total revenue | 210 | 284 | 248
Astellas Agreement [Member] | Development Revenue [Member] | Europe [Member] |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |
Total revenue | 6,452 | 9,624 | 21,679
AstraZeneca Agreements [Member] | License Revenue [Member] | U.S./RoW and China [Member] |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |
Total revenue | 2,649 | 0 | 0
AstraZeneca Agreements [Member] | Development Revenue [Member] | U.S./RoW and China [Member] |  |  |
Revenue Recognition Multiple Deliverable Arrangements [Line Items] |  |  |
Total revenue | $ 9,473 | $ 12,519 | $ 48,345

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