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Collaboration Agreements, License Agreement and Revenues - Product Revenue, Net - Additional Information 1 (Detail) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2021
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Total revenue | $ 147,752 | $ 140,734 | $ 235,309
Product Revenue, Net [Member] |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Total revenue | 100,949 | 82,869 | $ 47,638
Product Revenue, Net [Member] | Beijing Falikang Pharmaceutical Co Ltd |  |  |
Contract with Customer, Liability [Abstract] |  |  |
Reductions to gross accounts receivable | 3,000 | 500 |
China [Member] |  |  |
Contract with Customer, Liability [Abstract] |  |  |
Recognized as Revenue | 500 |  |
China [Member] | Product Revenue, Net [Member] |  |  |
Contract with Customer, Liability [Abstract] |  |  |
Contract with customer liability increase decrease in revenue due to changes to estimated variable consideration | 2,900 |  |
AstraZeneca Agreements [Member] |  |  |
Contract with Customer, Liability [Abstract] |  |  |
Deferred Revenue | 179,851 | 175,646 |
Recognized as Revenue | 89,055 |  |
AstraZeneca Agreements [Member] | China [Member] |  |  |
Contract with Customer, Liability [Abstract] |  |  |
Deferred Revenue | 32,000 |  |
Recognized as Revenue | $ 3,500 |  |
Constrained for Future Recognition [Member] |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Total revenue |  | $ 2,300 |

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