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Balance Sheet Components - Additional Information (Detail) - USD ($) |  | 3 Months Ended | 12 Months Ended |
--- | --- | --- | --- | ---
Jul. 14, 2023 | Sep. 30, 2023 | Dec. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2021 | Jul. 31, 2021
Schedule of Available-for-sale Securities [Line Items] |  |  |  |  |  |
Other-than-temporary impairment loss |  |  | $ 0 |  |  |
Net unbilled co-development revenue |  |  | 0 | $ 0 |  |
Litigation settlement receivable |  |  | 28,500,000 |  |  |
Depreciation expense |  |  | 9,518,000 | 10,017,000 | $ 10,170,000 |
API and bulk drug product price true-up |  |  | 50,978,000 | 75,055,000 |  |
Accrued litigation settlement |  |  | 28,500,000 |  |  |
Restructuring plan, expected reduction to workforce, percentage | 32.00% |  |  |  |  |
Restructuring plan, non-recurring charges |  | $ 12,600,000 | 12,606,000 | 0 | $ 0 |
Cash payments for restructuring |  |  | 8,900,000 |  |  |
Accrued restructuring charges |  |  | 3,700,000 |  |  |
Cash and cash equivalents |  |  | 113,688,000 | 155,700,000 |  |
Eluminex Agreements [Member] |  |  |  |  |  |
Schedule of Available-for-sale Securities [Line Items] |  |  |  |  |  |
Aggregate consideration received for milestone and upfront payments |  |  | 4,000,000.0 |  |  | $ 8,000,000
AstraZeneca Agreements [Member] |  |  |  |  |  |
Schedule of Available-for-sale Securities [Line Items] |  |  |  |  |  |
Net unbilled co-development revenue |  |  | 22,500,000 | 17,500,000 |  |
Foreign subsidiaries [Member] |  |  |  |  |  |
Schedule of Available-for-sale Securities [Line Items] |  |  |  |  |  |
Cash and cash equivalents |  |  | $ 32,200,000 | $ 92,500,000 |  |

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