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Income Taxes (Tables) | 12 Months Ended
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Dec. 31, 2023
Income Tax Disclosure [Abstract] |
Schedule of Components of Loss Before Income Taxes | The components of loss before income taxes are as follows (in thousands):
|  | Years Ended December 31, |
|  | 2023 |  |  | 2022 |  |  | 2021 |
Domestic |  | $ | (328,475 | ) |  | $ | (307,056 | ) |  | $ | (268,499 | )
Foreign |  |  | 41,608 |  |  |  | 12,187 |  |  |  | (22,184 | )
Loss before provision for income taxes |  | $ | (286,867 | ) |  | $ | (294,869 | ) |  | $ | (290,683 | )
Schedule of Components of Provision For Income Taxes | The provision for income taxes consists of the following (in thousands):
|  | Years Ended December 31, |
|  | 2023 |  |  | 2022 |  |  | 2021 |
Current: |  |  |  |  |  |  |  |  |
Federal |  | $ | — |  |  | $ | — |  |  | $ | — |
State |  |  | — |  |  |  | — |  |  |  | — |
Foreign |  |  | 3 |  |  |  | 358 |  |  |  | 347 |
Total current |  |  | 3 |  |  |  | 358 |  |  |  | 347 |
Deferred: |  |  |  |  |  |  |  |  |
Federal |  |  | — |  |  |  | — |  |  |  | — |
State |  |  | — |  |  |  | — |  |  |  | — |
Foreign |  |  | — |  |  |  | — |  |  |  | — |
Total deferred |  |  | — |  |  |  | — |  |  |  | — |
Total provision for income taxes |  | $ | 3 |  |  | $ | 358 |  |  | $ | 347 |
Schedule of Reconciliation Between Statutory Federal Income Tax Rate and Effective Tax Rate | The following is the reconciliation between the statutory federal income tax rate and the Company’s effective tax rate:
| Years Ended December 31, |
| 2023 |  |  | 2022 |  |  | 2021 |
Tax at statutory federal rate |  | 21.0 | % |  |  | 21.0 | % |  |  | 21.0 | %
State tax |  | — | % |  |  | — | % |  |  | — | %
Stock-based compensation expense |  | (1.1 | )% |  |  | (2.5 | )% |  |  | (1.8 | )%
Net operating losses not benefitted |  | (17.9 | )% |  |  | (16.3 | )% |  |  | (16.8 | )%
Foreign net operating losses not benefitted |  | 3.0 | % |  |  | 0.9 | % |  |  | (1.6 | )%
Deduction limitation on executive compensation |  | (0.5 | )% |  |  | (0.2 | )% |  |  | (0.3 | )%
Global intangible low-taxed income |  | (4.3 | )% |  |  | (2.8 | )% |  |  | (0.4 | )%
Other |  | (0.2 | )% |  |  | (0.2 | )% |  |  | (0.2 | )%
Total |  | — | % |  |  | (0.1 | )% |  |  | (0.1 | )%
Schedule of Significant Components of Deferred Tax Assets | Significant components of the Company’s deferred tax assets are as follows (in thousands):
|  | December 31, |
|  | 2023 |  |  | 2022 |
Federal and state net operating loss carryforwards |  | $ | 175,257 |  |  | $ | 166,708 |
Tax credit carryforwards |  |  | 123,156 |  |  |  | 106,131 |
Foreign net operating loss carryforwards |  |  | 48,396 |  |  |  | 49,990 |
Capitalized research and development expenses |  |  | 81,697 |  |  |  | 45,125 |
Stock-based compensation |  |  | 9,155 |  |  |  | 8,616 |
Lease obligations |  |  | 17,189 |  |  |  | 18,442 |
Reserves and accruals |  |  | 5,475 |  |  |  | 4,929 |
Deferred revenue |  |  | 24,792 |  |  |  | 21,624 |
Intangible assets |  |  | 63,146 |  |  |  | 69,159 |
Other |  |  | 698 |  |  |  | 1,277 |
Subtotal |  |  | 548,961 |  |  |  | 492,001 |
Less: Valuation allowance |  |  | (534,967 | ) |  |  | (477,969 | )
Net deferred tax assets |  |  | 13,994 |  |  |  | 14,032 |
Fixed assets |  |  | (10,511 | ) |  |  | (13,101 | )
Non-deductible accrued expenses |  |  | (3,483 | ) |  |  | (931 | )
Net deferred tax liabilities |  |  | (13,994 | ) |  |  | (14,032 | )
Total net deferred tax assets |  | $ | — |  |  | $ | — |
Schedule of Reconciliation of the Beginning and Ending Amounts of Unrecognized Income Tax Benefits | A reconciliation of the beginning and ending amounts of unrecognized income tax benefits during the three years ended December 31, 2023 is as follows (in thousands):
|  | Federal and State |
Balance as of December 31, 2020 |  | $ | 48,574 |
Decrease due to prior positions |  |  | (245 | )
Increase due to current year position |  |  | 8,415 |
Foreign exchange rate differential |  |  | 927 |
Balance as of December 31, 2021 |  |  | 57,671 |
Increase due to prior positions |  |  | 6,954 |
Increase due to current year position |  |  | 9,074 |
Foreign exchange rate differential |  |  | (908 | )
Balance as of December 31, 2022 |  |  | 72,791 |
Decrease due to prior positions |  |  | (154 | )
Increase due to current year position |  |  | 8,805 |
Foreign exchange rate differential |  |  | (477 | )
Balance as of December 31, 2023 |  | $ | 80,965 |

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