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Income Taxes (Tables)

12 Months Ended

Dec. 31, 2023

Income Tax Disclosure [Abstract]

Schedule of Components of Loss Before Income Taxes

The components of loss before income taxes are as follows (in thousands):

		Years Ended December 31,
		2023				2022				2021
Domestic		$	(328,475	)		$	(307,056	)		$	(268,499	)
Foreign			41,608				12,187				(22,184	)
Loss before provision for income taxes		$	(286,867	)		$	(294,869	)		$	(290,683	)

Schedule of Components of Provision For Income Taxes

The provision for income taxes consists of the following (in thousands):

		Years Ended December 31,
		2023				2022				2021
Current:
Federal		$	—			$	—			$	—
State			—				—				—
Foreign			3				358				347
Total current			3				358				347
Deferred:
Federal			—				—				—
State			—				—				—
Foreign			—				—				—
Total deferred			—				—				—
Total provision for income taxes		$	3			$	358			$	347

Schedule of Reconciliation Between Statutory Federal Income Tax Rate and Effective Tax Rate

The following is the reconciliation between the statutory federal income tax rate and the Company’s effective tax rate:

	Years Ended December 31,
	2023				2022				2021
Tax at statutory federal rate		21.0	%			21.0	%			21.0	%
State tax		—	%			—	%			—	%
Stock-based compensation expense		(1.1	)%			(2.5	)%			(1.8	)%
Net operating losses not benefitted		(17.9	)%			(16.3	)%			(16.8	)%
Foreign net operating losses not benefitted		3.0	%			0.9	%			(1.6	)%
Deduction limitation on executive compensation		(0.5	)%			(0.2	)%			(0.3	)%
Global intangible low-taxed income		(4.3	)%			(2.8	)%			(0.4	)%
Other		(0.2	)%			(0.2	)%			(0.2	)%
Total		—	%			(0.1	)%			(0.1	)%

Schedule of Significant Components of Deferred Tax Assets

Significant components of the Company’s deferred tax assets are as follows (in thousands):

		December 31,
		2023				2022
Federal and state net operating loss carryforwards		$	175,257			$	166,708
Tax credit carryforwards			123,156				106,131
Foreign net operating loss carryforwards			48,396				49,990
Capitalized research and development expenses			81,697				45,125
Stock-based compensation			9,155				8,616
Lease obligations			17,189				18,442
Reserves and accruals			5,475				4,929
Deferred revenue			24,792				21,624
Intangible assets			63,146				69,159
Other			698				1,277
Subtotal			548,961				492,001
Less: Valuation allowance			(534,967	)			(477,969	)
Net deferred tax assets			13,994				14,032
Fixed assets			(10,511	)			(13,101	)
Non-deductible accrued expenses			(3,483	)			(931	)
Net deferred tax liabilities			(13,994	)			(14,032	)
Total net deferred tax assets		$	—			$	—

Schedule of Reconciliation of the Beginning and Ending Amounts of Unrecognized Income Tax Benefits

A reconciliation of the beginning and ending amounts of unrecognized income tax benefits during the three years ended December 31, 2023 is as follows (in thousands):

		Federal and State
Balance as of December 31, 2020		$	48,574
Decrease due to prior positions			(245	)
Increase due to current year position			8,415
Foreign exchange rate differential			927
Balance as of December 31, 2021			57,671
Increase due to prior positions			6,954
Increase due to current year position			9,074
Foreign exchange rate differential			(908	)
Balance as of December 31, 2022			72,791
Decrease due to prior positions			(154	)
Increase due to current year position			8,805
Foreign exchange rate differential			(477	)
Balance as of December 31, 2023		$	80,965

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