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Collaboration Agreements, License Agreement and Revenues - Summary of License Revenue and Development Revenue Recognized under Agreement (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021
Revenue Recognition Multiple Deliverable Arrangements [Line Items]
Total revenue	$ 147,752	$ 140,734	$ 235,309
License Revenue [Member]
Revenue Recognition Multiple Deliverable Arrangements [Line Items]
Total revenue	9,649	22,590	116,434
Development Revenue [Member]
Revenue Recognition Multiple Deliverable Arrangements [Line Items]
Total revenue	18,401	24,189	70,275
Astellas Agreement [Member] | License Revenue [Member] | Europe [Member]
Revenue Recognition Multiple Deliverable Arrangements [Line Items]
Total revenue	0	22,590	108,434
Astellas Agreement [Member] | Development Revenue [Member] | Japan [Member]
Revenue Recognition Multiple Deliverable Arrangements [Line Items]
Total revenue	210	284	248
Astellas Agreement [Member] | Development Revenue [Member] | Europe [Member]
Revenue Recognition Multiple Deliverable Arrangements [Line Items]
Total revenue	6,452	9,624	21,679
AstraZeneca Agreements [Member] | License Revenue [Member] | U.S./RoW and China [Member]
Revenue Recognition Multiple Deliverable Arrangements [Line Items]
Total revenue	2,649	0	0
AstraZeneca Agreements [Member] | Development Revenue [Member] | U.S./RoW and China [Member]
Revenue Recognition Multiple Deliverable Arrangements [Line Items]
Total revenue	$ 9,473	$ 12,519	$ 48,345

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- Definition

Amount, excluding tax collected from customer, of revenue from satisfaction of performance obligation by transferring promised good or service to customer. Tax collected from customer is tax assessed by governmental authority that is both imposed on and concurrent with specific revenue-producing transaction, including, but not limited to, sales, use, value added and excise.

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Reference 1: http://www.xbrl.org/2003/role/disclosureRef
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