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Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2023
Dec. 31, 2022
Dec. 31, 2021
Operating activities      
Net loss $ (284,232) $ (293,654) $ (290,023)
Adjustments to reconcile net loss to net cash used in operating activities:      
Depreciation 9,518 10,017 10,170
Amortization of finance lease right-of-use assets 412 587 4,639
Net accretion of premium and discount on investments (5,061) 1,619 2,482
Unrealized loss on equity investments 0 0 30
Investment income in unconsolidated variable interest entity (2,638) (1,573) (1,007)
Loss (gain) on disposal of property and equipment 4 (1) 233
Stock-based compensation 50,767 65,601 71,161
Acquired In-process Research and Development Expenses 24,636 0 60,000
Non-cash interest expense related to sale of future revenues 7,734 1,036 0
Dividend received from unconsolidated variable interest entity 2,255 0 0
Impairment of investment 1,000 0 0
Realized loss on sales of available-for-sale securities 271 5 0
Changes in operating assets and liabilities:      
Accounts receivable, net ($6,009, $(1,158) and $(6,803) from related parties) 3,433 765 25,180
Inventories (1,695) (10,999) (14,158)
Prepaid expenses and other current assets ($0, $0 and $889 from a related party) (28,165) 4,916 (9,854)
Operating lease right-of-use assets 11,704 10,908 4,209
Other assets 256 263 (4,412)
Accounts payable ($0, $0 and $(1,118) from a related party) (15,514) 5,909 805
Accrued and other liabilities ($(24,072), $63,882 and $(20) from a related party) (49,778) 90,556 16,380
Operating lease liabilities, current 3,820 (547) 503
Deferred revenue ($(23,378), $11,211 and $21,549 from related parties) (28,166) (4,130) 57,637
Accrued interest for finance lease liabilities (11) 33 (75)
Operating lease liabilities, non-current (12,998) (8,994) (4,043)
Other long-term liabilities (2,573) (18,250) (12,089)
Net cash used in operating activities (315,021) (145,933) (82,232)
Investing activities      
Purchases of property and equipment (2,519) (3,741) (5,186)
Payment made for acquired in-process research and development asset 0 (35,000) (25,000)
Proceeds from sale of property and equipment 0 6 0
Purchases of available-for-sale securities (251,830) (164,023) (484,144)
Cash acquired from consolidation of Fortis 656 0 0
Proceeds from sales of available-for-sale securities 6,729 7,382 4,214
Proceeds from maturities of investments 400,621 284,492 83,144
Net cash provided by (used in) investing activities 153,657 89,116 (426,972)
Financing activities      
Proceeds from senior secured term loan facilities, net of issuance costs 74,078 0 0
Cash paid for transaction costs for senior secured term loan facilities (2,746) 0 0
Repayments of finance lease liabilities (148) (135) (5,489)
Repayments of lease obligations (336) (403) (403)
Cash paid for payroll taxes on restricted stock unit releases (237) (5,167) (7,372)
Proceeds from sale of future revenues, net of issuance costs 0 49,750 0
Cash paid for transaction costs related to sale of future revenues 0 (1,453) 0
Proceeds from issuance of common stock under ATM Program, net of commissions 48,407 0 0
Proceeds from issuance of common stock under employee stock plans 3,731 4,184 12,701
Net cash provided by (used in) financing activities 122,749 46,776 (563)
Effect of exchange rate change on cash and cash equivalents (3,397) (5,482) 2,597
Net decrease in cash and cash equivalents (42,012) (15,523) (507,170)
Total cash and cash equivalents at beginning of period 155,700 171,223 678,393
Total cash and cash equivalents at end of period 113,688 155,700 171,223
Supplemental Cash Flow Information [Abstract]      
Non cash acquisition in Fortis (22,000) 0 0
Interest payments 54 104 94
Balance in accounts payable and accrued liabilities related to purchases of property and equipment 103 428 1,009
Balance in accrued liabilities related to issuance costs of secured term loan facilities 0 0 35,000
Balance in other receivables related to stock option exercise 0 0 165
Conversion of subsidiary's convertible note payable to non-controlling interests $ 0 $ 0 $ 696