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Collaboration Agreements, License Agreement and Revenues - AstraZeneca Agreements - Additional Information 1 (Detail) - USD ($) $ in Thousands		3 Months Ended
	Jul. 30, 2013	Mar. 31, 2024	Sep. 30, 2023	Mar. 31, 2023	Dec. 31, 2023	Sep. 18, 2023
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Total revenue		$ 55,902		$ 36,161
Deferred Revenue		12,863			$ 12,740
Drug product revenue recognized		55,902		36,161
Product [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Total revenue		30,538		24,161
Drug product revenue recognized		30,538		24,161
Drug Product Revenue, Net [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Total revenue		24,486		2,109
Drug product revenue recognized		24,486		2,109
Drug Product Revenue, Net [Member] | API Shipment [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Total revenue		2,200
Drug product revenue recognized		2,200
Japan [Member] | Drug Product Revenue, Net [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Total revenue				1,700
Drug product revenue recognized				1,700
AstraZeneca Agreements [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Recognized as Revenue		27,113
AstraZeneca Agreements [Member] | U.S./RoW [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Aggregate considerations received		439,000
AstraZeneca Agreements [Member] | China [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Upfront, non-contingent, non-refundable and time-based payments	$ 376,700
Aggregate considerations received		77,200
Transaction price and allocated to performance obligations						$ 4,000
Recognized as Revenue			$ 3,500
Contract asset		4,000
Direct Sales [Member] | Product [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Total revenue		3,425		2,789
Drug product revenue recognized		$ 3,425		$ 2,789

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