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Condensed Consolidated Statement of Cash Flows (Unaudited) - USD ($) $ in Thousands | 6 Months Ended
--- | ---
Jun. 30, 2024 | Jun. 30, 2023
Operating activities |  |
Net loss | $ (48,477) | $ (164,385)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation | 1,582 | 5,020
Amortization of finance lease right-of-use assets | 19 | 657
Net accretion of premium and discount on investments | (1,681) | (1,815)
Investment income in unconsolidated variable interest entity | (1,766) | (1,346)
Loss on disposal of property and equipment | 306 | 1
Stock-based compensation | 17,350 | 31,995
Acquired in-process research and development expenses | 0 | 24,636
Non-cash interest expense related to sale of future revenues | 0 | 3,577
Impairment of investment | 0 | 1,000
Realized loss on sales of available-for-sale securities | 0 | 271
Changes in operating assets and liabilities: |  |
Accounts receivable, net | 5,962 | (10,007)
Inventories | 15,578 | (1,951)
Prepaid expenses and other current assets | 4,527 | 4,199
Operating lease right-of-use assets | 6,806 | 5,296
Other assets | 441 | 99
Accounts payable | (7,977) | (20,784)
Accrued and other liabilities | (52,663) | (57,016)
Operating lease liabilities, current | 1,489 | 787
Deferred revenue | (29,501) | (25,555)
Accrued interest expense related to sale of future revenues | (1,904) | 0
Accrued interest for finance lease liabilities | 12 | 68
Operating lease liabilities, non-current | (8,128) | (5,666)
Other long-term liabilities | (1,132) | (1,243)
Net cash used in operating activities | (99,157) | (212,162)
Investing activities |  |
Purchases of property and equipment | (43) | (1,584)
Proceeds from sale of property and equipment | 3 | 0
Purchases of available-for-sale securities | (8,628) | (104,543)
Cash acquired from consolidation of Fortis | 0 | 656
Proceeds from sales of available-for-sale securities | 0 | 1,730
Proceeds from maturities of investments | 132,183 | 192,938
Net cash provided by investing activities | 123,515 | 89,197
Financing activities |  |
Proceeds from senior secured term loan facilities, net of issuance costs | 0 | 74,078
Cash paid for transaction costs for senior secured term loan facilities | 0 | (2,746)
Repayments of finance lease liabilities | (20) | (207)
Repayments of lease obligations | 0 | (201)
Cash paid for payroll taxes on restricted stock unit releases | (229) | 0
Proceeds from issuance of common stock under ATM Program, net of commissions | 0 | 48,407
Proceeds from issuance of common stock under employee stock plans | 116 | 3,686
Net cash provided by (used in) financing activities | (133) | 123,017
Effect of exchange rate change on cash and cash equivalents | 2,801 | (3,167)
Net increase (decrease) in cash and cash equivalents | 27,026 | (3,115)
Total cash and cash equivalents at beginning of period | 113,688 | 155,700
Total cash and cash equivalents at end of period | $ 140,714 | $ 152,585

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