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Collaboration Agreements, License Agreement and Revenues - Product Revenue, Net - Additional Information 1 (Detail) - USD ($) $ in Thousands | 3 Months Ended | 6 Months Ended |
--- | --- | --- | ---
Jun. 30, 2024 | Jun. 30, 2023 | Jun. 30, 2024 | Jun. 30, 2023 | Dec. 31, 2023
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |
Total revenue | $ 50,641 | $ 44,319 | $ 106,544 | $ 80,480 |
Contract with Customer, Liability [Abstract] |  |  |  |  |
Deferred revenue, net of current | 131,192 |  | 131,192 |  | $ 157,555
Net unbilled milestone and co-development revenue | 0 |  | 0 |  | 0
Constrained for Future Recognition [Member] |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |
Total revenue | 18,100 | 3,300 | 20,600 | 1,200 |
Product Revenue, Net [Member] |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |
Total revenue | 49,643 | $ 23,889 | 80,181 | $ 48,049 |
China [Member] | Product Revenue, Net [Member] |  |  |  |  |
Contract with Customer, Liability [Abstract] |  |  |  |  |
Contract with customer liability increase decrease in revenue due to changes to estimated variable consideration | 12,200 |  |  |  |
AstraZeneca Agreements [Member] |  |  |  |  |
Contract with Customer, Liability [Abstract] |  |  |  |  |
Deferred Revenue | 158,593 |  | 158,593 |  | 179,851
Deferred revenue, net of current | 131,300 |  | 131,300 |  |
Net unbilled milestone and co-development revenue | 23,300 |  | 23,300 |  | 22,500
AstraZeneca Agreements [Member] | China performance obligation [Member] |  |  |  |  |
Contract with Customer, Liability [Abstract] |  |  |  |  |
Deferred Revenue | 158,600 |  | 158,600 |  |
Net unbilled milestone and co-development revenue | 27,300 |  | 27,300 |  |
AstraZeneca Agreements [Member] | China [Member] |  |  |  |  |
Contract with Customer, Liability [Abstract] |  |  |  |  |
Deferred Revenue | 3,400 |  | 3,400 |  |
Beijing Falikang Pharmaceutical Co Ltd | Product Revenue, Net [Member] |  |  |  |  |
Contract with Customer, Liability [Abstract] |  |  |  |  |
Reductions to gross accounts receivable | $ 2,300 |  | $ 2,300 |  | $ 3,000

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