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Collaboration Agreements, License Agreement and Revenues - AstraZeneca Agreements - Additional Information 1 (Detail) - USD ($) $ in Thousands |  | 3 Months Ended | 6 Months Ended |  |
--- | --- | --- | --- | --- | ---
Jul. 30, 2013 | Jun. 30, 2024 | Mar. 31, 2024 | Jun. 30, 2023 | Mar. 31, 2023 | Jun. 30, 2024 | Jun. 30, 2023 | Dec. 31, 2023 | Sep. 18, 2023
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Total revenue |  | $ 50,641 |  | $ 44,319 |  | $ 106,544 | $ 80,480 |  |
Deferred Revenue |  | 9,546 |  |  |  | 9,546 |  | $ 12,740 |
Drug product revenue recognized |  | 50,641 |  | 44,319 |  | 106,544 | 80,480 |  |
Product [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Total revenue |  | 49,643 |  | 23,889 |  | 80,181 | 48,049 |  |
Drug product revenue recognized |  | 49,643 |  | 23,889 |  | 80,181 | 48,049 |  |
Drug Product Revenue, Net [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Total revenue |  | 729 |  | 14,272 |  | 25,216 | 16,381 |  |
Drug product revenue recognized |  | 729 |  | 14,272 |  | 25,216 | 16,381 |  |
Drug Product Revenue, Net [Member] | API Shipment [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Total revenue |  | 400 | $ 2,200 | 600 |  |  |  |  |
Drug product revenue recognized |  | 400 | $ 2,200 | 600 |  |  |  |  |
Japan [Member] | Drug Product Revenue, Net [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Total revenue |  |  |  | 14,400 | $ 1,700 |  |  |  |
Drug product revenue recognized |  |  |  | 14,400 | $ 1,700 |  |  |  |
AstraZeneca Agreements [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Recognized as Revenue |  |  |  |  |  | 73,118 |  |  |
AstraZeneca Agreements [Member] | U.S./RoW [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Aggregate considerations received |  |  |  |  |  | 439,000 |  |  |
AstraZeneca Agreements [Member] | China [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Upfront, non-contingent, non-refundable and time-based payments | $ 376,700 |  |  |  |  |  |  |  |
Aggregate considerations received |  |  |  |  |  | 77,200 |  |  |
Transaction price and allocated to performance obligations |  |  |  |  |  |  |  |  | $ 4,000
Contract asset |  | 4,000 |  |  |  | 4,000 |  |  |
Direct Sales [Member] | Product [Member] |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Total revenue |  | 3,638 |  | 3,377 |  | 7,063 | 6,165 |  |
Drug product revenue recognized |  | $ 3,638 |  | $ 3,377 |  | $ 7,063 | $ 6,165 |  |

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