Subsequent Event	6 Months Ended
Jun. 30, 2024
Subsequent Events [Abstract]
Subsequent Event	11. Subsequent Event On July 30, 2024, the Company reported results from Pancreatic Cancer Action Network’s (“PanCAN’s”) Precision PromiseSM adaptive trial platform that included pamrevlumab, its antibody developed to inhibit the activity of CTGF, in combination with standard-of-care chemotherapy treatments for pancreatic cancer, for patients with metastatic pancreatic cancer. The pamrevlumab experimental arm in PanCAN’s Precision Promise Phase 2/3 adaptive platform trial did not meet the primary endpoint of overall survival as determined by the protocol pre-specified Bayesian statistical analysis. On July 30, 2024, the Company also reported results from LAPIS, its double-blind placebo-controlled Phase 3 clinical program for pamrevlumab in 284 LAPC patients randomized at a 1:1 ratio to receive either pamrevlumab or placebo, in each case in combination with chemotherapy (either FOLFIRINOX or gemcitabine plus nab-paclitaxel). The study did not meet the primary endpoint of overall survival. Responding to the above results, the Company is implementing an immediate and significant cost reduction plan in the U.S., including terminating pamrevlumab research and development investment and expeditiously wind down remaining obligations, and reducing U.S. workforce by approximately 75% (the Company notified employees on August 2, 2024). The Company expects that the majority of the restructuring charges related to the headcount reductions, primarily consisting of notice period and severance payments, accrued vacation and employee benefits contributions, will be recognized in the second half of 2024, and that the implementation of the headcount reductions, including cash payments, will be substantially complete by the end of the first quarter of 2025. The Company may incur additional expenses not currently contemplated due to events associated with these cost reduction measures.

Subsequent Event

6 Months Ended

Jun. 30, 2024

11. Subsequent Event

On July 30, 2024, the Company reported results from Pancreatic Cancer Action Network’s (“PanCAN’s”) Precision PromiseSM adaptive trial platform that included pamrevlumab, its antibody developed to inhibit the activity of CTGF, in combination with standard-of-care chemotherapy treatments for pancreatic cancer, for patients with metastatic pancreatic cancer. The pamrevlumab experimental arm in PanCAN’s Precision Promise Phase 2/3 adaptive platform trial did not meet the primary endpoint of overall survival as determined by the protocol pre-specified Bayesian statistical analysis.

On July 30, 2024, the Company also reported results from LAPIS, its double-blind placebo-controlled Phase 3 clinical program for pamrevlumab in 284 LAPC patients randomized at a 1:1 ratio to receive either pamrevlumab or placebo, in each case in combination with chemotherapy (either FOLFIRINOX or gemcitabine plus nab-paclitaxel). The study did not meet the primary endpoint of overall survival.

Responding to the above results, the Company is implementing an immediate and significant cost reduction plan in the U.S., including terminating pamrevlumab research and development investment and expeditiously wind down remaining obligations, and reducing U.S. workforce by approximately 75% (the Company notified employees on August 2, 2024). The Company expects that the majority of the restructuring charges related to the headcount reductions, primarily consisting of notice period and severance payments, accrued vacation and employee benefits contributions, will be recognized in the second half of 2024, and that the implementation of the headcount reductions, including cash payments, will be substantially complete by the end of the first quarter of 2025. The Company may incur additional expenses not currently contemplated due to events associated with these cost reduction measures.