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Collaboration Agreements, License Agreement and Revenues - AstraZeneca Agreements - Additional Information 1 (Detail) - USD ($) $ in Thousands		3 Months Ended				6 Months Ended
	Jul. 30, 2013	Jun. 30, 2024	Mar. 31, 2024	Jun. 30, 2023	Mar. 31, 2023	Jun. 30, 2024	Jun. 30, 2023	Dec. 31, 2023	Sep. 18, 2023
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Total revenue		$ 50,641		$ 44,319		$ 106,544	$ 80,480
Deferred Revenue		9,546				9,546		$ 12,740
Drug product revenue recognized		50,641		44,319		106,544	80,480
Product [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Total revenue		49,643		23,889		80,181	48,049
Drug product revenue recognized		49,643		23,889		80,181	48,049
Drug Product Revenue, Net [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Total revenue		729		14,272		25,216	16,381
Drug product revenue recognized		729		14,272		25,216	16,381
Drug Product Revenue, Net [Member] | API Shipment [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Total revenue		400	$ 2,200	600
Drug product revenue recognized		400	$ 2,200	600
Japan [Member] | Drug Product Revenue, Net [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Total revenue				14,400	$ 1,700
Drug product revenue recognized				14,400	$ 1,700
AstraZeneca Agreements [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Recognized as Revenue						73,118
AstraZeneca Agreements [Member] | U.S./RoW [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Aggregate considerations received						439,000
AstraZeneca Agreements [Member] | China [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Upfront, non-contingent, non-refundable and time-based payments	$ 376,700
Aggregate considerations received						77,200
Transaction price and allocated to performance obligations									$ 4,000
Contract asset		4,000				4,000
Direct Sales [Member] | Product [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Total revenue		3,638		3,377		7,063	6,165
Drug product revenue recognized		$ 3,638		$ 3,377		$ 7,063	$ 6,165

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