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Collaboration Agreements, License Agreement and Revenues - AstraZeneca Agreements - Additional Information 1 (Detail) - USD ($) $ in Thousands		3 Months Ended						9 Months Ended
	Jul. 30, 2013	Sep. 30, 2024	Jun. 30, 2024	Mar. 31, 2024	Sep. 30, 2023	Jun. 30, 2023	Mar. 31, 2023	Sep. 30, 2024	Sep. 30, 2023	Dec. 31, 2023	Sep. 18, 2023
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Total revenue		$ 46,333			$ 40,134			$ 152,877	$ 120,614
Deferred Revenue		28,858						28,858		$ 12,740
Drug product revenue recognized		46,333			40,134			152,877	120,614
Product [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Total revenue		46,210			29,390			126,391	77,439
Drug product revenue recognized		46,210			29,390			126,391	77,439
Drug Product Revenue, Net [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Total revenue		(262)			1,320			24,954	17,701
Drug product revenue recognized		(262)			1,320			24,954	17,701
Drug Product Revenue, Net [Member] | API Shipment [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Total revenue		1,400	$ 400	$ 2,200	700	$ 600
Drug product revenue recognized		1,400	$ 400	$ 2,200	700	600
Japan [Member] | Drug Product Revenue, Net [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Total revenue						14,400	$ 1,700
Drug product revenue recognized						$ 14,400	$ 1,700
AstraZeneca Agreements [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Recognized as Revenue								115,339
AstraZeneca Agreements [Member] | U.S./RoW [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Aggregate considerations received								439,000
AstraZeneca Agreements [Member] | China [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Upfront, non-contingent, non-refundable and time-based payments	$ 376,700
Aggregate considerations received								77,200
Transaction price and allocated to performance obligations											$ 4,000
Contract asset		4,000						4,000
Direct Sales [Member] | Product [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Total revenue		3,989			2,927			11,052	9,092
Drug product revenue recognized		$ 3,989			$ 2,927			$ 11,052	$ 9,092

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