<?xml version="1.0" encoding="US-ASCII"?>
<!-- DFIN New ActiveDisclosure (SM) XBRL Schema Document - http://www.dfinsolutions.com/ -->
<!-- Creation Date :2024-04-24T16:59:03.9293+00:00 -->
<!-- Copyright (c) 2024 Donnelly Financial Solutions, Inc. All Rights Reserved. -->
<xsd:schema targetNamespace="http://www.fibrogen.com/20240424" attributeFormDefault="unqualified" elementFormDefault="qualified" xmlns:dtr-types="http://www.xbrl.org/dtr/type/2022-03-31" xmlns:enum2="http://xbrl.org/2020/extensible-enumerations-2.0" xmlns:ecd-sub="http://xbrl.sec.gov/ecd-sub/2023" xmlns:fgen="http://www.fibrogen.com/20240424" xmlns:ecd="http://xbrl.sec.gov/ecd/2023" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:us-gaap="http://fasb.org/us-gaap/2023" xmlns:dei="http://xbrl.sec.gov/dei/2023" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:xlink="http://www.w3.org/1999/xlink">
  <xsd:import schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd" namespace="http://www.xbrl.org/2003/instance"/>
  <xsd:import schemaLocation="http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd" namespace="http://www.xbrl.org/2003/linkbase"/>
  <xsd:import schemaLocation="http://www.xbrl.org/2005/xbrldt-2005.xsd" namespace="http://xbrl.org/2005/xbrldt"/>
  <xsd:import schemaLocation="https://xbrl.sec.gov/dei/2023/dei-2023.xsd" namespace="http://xbrl.sec.gov/dei/2023"/>
  <xsd:import schemaLocation="https://xbrl.sec.gov/ecd/2023/ecd-sub-2023.xsd" namespace="http://xbrl.sec.gov/ecd-sub/2023"/>
  <xsd:import schemaLocation="https://xbrl.fasb.org/us-gaap/2023/elts/us-gaap-2023.xsd" namespace="http://fasb.org/us-gaap/2023"/>
  <xsd:import schemaLocation="https://www.xbrl.org/dtr/type/2022-03-31/types.xsd" namespace="http://www.xbrl.org/dtr/type/2022-03-31"/>
  <xsd:import schemaLocation="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd" namespace="http://xbrl.sec.gov/ecd/2023"/>
  <xsd:annotation>
    <xsd:appinfo>
      <link:roleType roleURI="http://www.fibrogen.com/20240424/taxonomy/role/DocumentDocumentAndEntityInformation" id="DocumentDocumentAndEntityInformation">
        <link:definition>100000 - Document - Document and Entity Information</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:linkbase id="lnk">
        <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all" xlink:type="simple"/>
        <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default" xlink:type="simple"/>
        <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain" xlink:type="simple"/>
        <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member" xlink:type="simple"/>
        <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension" xlink:type="simple"/>
        <link:roleRef roleURI="http://xbrl.sec.gov/ecd/role/PvpAdjustmentsOnly" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#PvpAdjustmentsOnly" xlink:type="simple"/>
        <link:roleRef roleURI="http://xbrl.sec.gov/ecd/role/IndividualsOnly" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#IndividualsOnly" xlink:type="simple"/>
        <link:roleRef roleURI="http://www.fibrogen.com/20240424/taxonomy/role/DocumentDocumentAndEntityInformation" xlink:href="fgen-20240424.xsd#DocumentDocumentAndEntityInformation" xlink:type="simple"/>
        <link:roleRef roleURI="http://xbrl.sec.gov/ecd/role/PvpDisclosure" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#PvpDisclosure" xlink:type="simple"/>
        <link:labelLink xlink:role="http://www.xbrl.org/2003/role/link" xlink:title="labelLink" xlink:type="extended">
          <link:loc xlink:type="locator" xlink:href="fgen-20240424.xsd#fgen_FairValueAsOfVestingDateOfEquityAwardsGrantedAndVestedInSameCoveredFiscalYearMember" xlink:label="fgen_FairValueAsOfVestingDateOfEquityAwardsGrantedAndVestedInSameCoveredFiscalYearMember"/>
          <link:loc xlink:type="locator" xlink:href="fgen-20240424.xsd#fgen_CompActuallyPaidAndTotalRevenueTextBlock" xlink:label="fgen_CompActuallyPaidAndTotalRevenueTextBlock"/>
          <link:loc xlink:type="locator" xlink:href="fgen-20240424.xsd#fgen_ChangeInFairValueOfOutstandingAndUnvestedEquityAwardsGrantedInPriorFiscalYearsThatVestedInCoveredFiscalYearMember" xlink:label="fgen_ChangeInFairValueOfOutstandingAndUnvestedEquityAwardsGrantedInPriorFiscalYearsThatVestedInCoveredFiscalYearMember"/>
          <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityCentralIndexKey" xlink:label="dei_EntityCentralIndexKey"/>
          <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityRegistrantName" xlink:label="dei_EntityRegistrantName"/>
          <link:loc xlink:type="locator" xlink:href="fgen-20240424.xsd#fgen_SecondPeoMember" xlink:label="fgen_SecondPeoMember"/>
          <link:loc xlink:type="locator" xlink:href="fgen-20240424.xsd#fgen_FirstPeoMember" xlink:label="fgen_FirstPeoMember"/>
          <link:loc xlink:type="locator" xlink:href="fgen-20240424.xsd#fgen_ChangeInFairValueOfOutstandingAndUnvestedEquityAwardsGrantedPriorFiscalYearsAsOfEndOfCoveredFiscalYearMember" xlink:label="fgen_ChangeInFairValueOfOutstandingAndUnvestedEquityAwardsGrantedPriorFiscalYearsAsOfEndOfCoveredFiscalYearMember"/>
          <link:loc xlink:type="locator" xlink:href="fgen-20240424.xsd#fgen_CompActuallyPaidVsRevenueTextBlock" xlink:label="fgen_CompActuallyPaidVsRevenueTextBlock"/>
          <link:loc xlink:type="locator" xlink:href="fgen-20240424.xsd#fgen_FairValueOutstandIngAndUnvestedEquityAwardsGrantedInPriorFiscalYearsFailedToMeetVestingConditionsMember" xlink:label="fgen_FairValueOutstandIngAndUnvestedEquityAwardsGrantedInPriorFiscalYearsFailedToMeetVestingConditionsMember"/>
          <link:loc xlink:type="locator" xlink:href="fgen-20240424.xsd#fgen_FairValueOfAllOutstandingAndUnvestedEquityAwardsGrantedMember" xlink:label="fgen_FairValueOfAllOutstandingAndUnvestedEquityAwardsGrantedMember"/>
          <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_CoverAbstract" xlink:label="dei_CoverAbstract"/>
          <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_AmendmentFlag" xlink:label="dei_AmendmentFlag"/>
          <link:loc xlink:type="locator" xlink:href="fgen-20240424.xsd#fgen_DollarValueOfDividendsOrOtherEarningsPaidOnStockOrOptionAwardsInCoveredFiscalYearPriorToVestingDateMember" xlink:label="fgen_DollarValueOfDividendsOrOtherEarningsPaidOnStockOrOptionAwardsInCoveredFiscalYearPriorToVestingDateMember"/>
          <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_DocumentType" xlink:label="dei_DocumentType"/>
          <link:loc xlink:type="locator" xlink:href="fgen-20240424.xsd#fgen_ThirdPeoMember" xlink:label="fgen_ThirdPeoMember"/>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="fgen_FairValueAsOfVestingDateOfEquityAwardsGrantedAndVestedInSameCoveredFiscalYearMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Fair Value As of Vesting Date of Equity Awards Granted And Vested in Same Covered Fiscal Year [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="fgen_FairValueAsOfVestingDateOfEquityAwardsGrantedAndVestedInSameCoveredFiscalYearMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value as of Vesting Date of Equity Awards Granted and Vested in Same Covered Fiscal Year [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="fgen_FairValueAsOfVestingDateOfEquityAwardsGrantedAndVestedInSameCoveredFiscalYearMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Fair value as of vesting date of equity awards granted and vested in same covered fiscal year.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="fgen_CompActuallyPaidAndTotalRevenueTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Compensation Actually Paid and Total Revenue</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="fgen_CompActuallyPaidAndTotalRevenueTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Comp Actually Paid and Total Revenue [Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="fgen_CompActuallyPaidAndTotalRevenueTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Comp actually paid and total revenue.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="fgen_ChangeInFairValueOfOutstandingAndUnvestedEquityAwardsGrantedInPriorFiscalYearsThatVestedInCoveredFiscalYearMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Change in Fair Value of Outstanding and Unvested Equity Awards Granted in Prior Fiscal Years that Vested in Covered Fiscal Year [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="fgen_ChangeInFairValueOfOutstandingAndUnvestedEquityAwardsGrantedInPriorFiscalYearsThatVestedInCoveredFiscalYearMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Change in fair value of outstanding and unvested equity awards granted in prior fiscal years vested in covered fiscal year.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityCentralIndexKey_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Entity Central Index Key</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_EntityRegistrantName_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Entity Registrant Name</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="fgen_SecondPeoMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Second PEO [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="fgen_SecondPeoMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Second PEO [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="fgen_SecondPeoMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Second PEO.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="fgen_FirstPeoMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">First PEO [Memeber]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="fgen_FirstPeoMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">First PEO [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="fgen_FirstPeoMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">First PEO.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="fgen_ChangeInFairValueOfOutstandingAndUnvestedEquityAwardsGrantedPriorFiscalYearsAsOfEndOfCoveredFiscalYearMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Change in Fair Value Of Outstanding and Unvested Equity Awards Granted Prior Fiscal Years As of End of Covered Fiscal Year [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="fgen_ChangeInFairValueOfOutstandingAndUnvestedEquityAwardsGrantedPriorFiscalYearsAsOfEndOfCoveredFiscalYearMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Change in Fair Value of Outstanding and Unvested Equity Awards Granted Prior Fiscal Years as of End of Covered Fiscal Year [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="fgen_ChangeInFairValueOfOutstandingAndUnvestedEquityAwardsGrantedPriorFiscalYearsAsOfEndOfCoveredFiscalYearMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Change in fair value of outstanding and unvested equity awards granted prior fiscal years as of end of covered fiscal year.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="fgen_CompActuallyPaidVsRevenueTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Compensation Actually Paid vs. Revenue</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="fgen_CompActuallyPaidVsRevenueTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Comp Actually Paid Vs Revenue [Text Block]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="fgen_CompActuallyPaidVsRevenueTextBlock_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Comp actually paid vs revenue.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="fgen_FairValueOutstandIngAndUnvestedEquityAwardsGrantedInPriorFiscalYearsFailedToMeetVestingConditionsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Fair Value Outstand-ing and Unvested Equity Awards Granted in Prior Fiscal Years Failed to Meet Vesting Conditions [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="fgen_FairValueOutstandIngAndUnvestedEquityAwardsGrantedInPriorFiscalYearsFailedToMeetVestingConditionsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value Outstand-ing and Unvested Equity Awards Granted in Prior Fiscal Years Failed to Meet Vesting Conditions [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="fgen_FairValueOutstandIngAndUnvestedEquityAwardsGrantedInPriorFiscalYearsFailedToMeetVestingConditionsMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Fair value outstand-ing and unvested equity awards granted in prior fiscal years failed to meet vesting conditions.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="fgen_FairValueOfAllOutstandingAndUnvestedEquityAwardsGrantedMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Fair Value of All Outstanding and Unvested Equity Awards Granted [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="fgen_FairValueOfAllOutstandingAndUnvestedEquityAwardsGrantedMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Fair Value of All Outstanding and Unvested Equity Awards Granted [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="fgen_FairValueOfAllOutstandingAndUnvestedEquityAwardsGrantedMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Fair value of all outstanding and unvested equity awards granted.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_CoverAbstract_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Cover [Abstract]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_AmendmentFlag_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Amendment Flag</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="fgen_DollarValueOfDividendsOrOtherEarningsPaidOnStockOrOptionAwardsInCoveredFiscalYearPriorToVestingDateMember_lbl" xlink:role="http://www.xbrl.org/2003/role/terseLabel">Dollar Value of Dividends or other Earnings Paid on Stock or Option Awards in Covered Fiscal Year Prior to Vesting Date [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="fgen_DollarValueOfDividendsOrOtherEarningsPaidOnStockOrOptionAwardsInCoveredFiscalYearPriorToVestingDateMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Dollar Value of Dividends or other Earnings Paid on Stock or Option Awards in Covered Fiscal Year Prior to Vesting Date [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="fgen_DollarValueOfDividendsOrOtherEarningsPaidOnStockOrOptionAwardsInCoveredFiscalYearPriorToVestingDateMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Dollar value of dividends or other earnings paid on stock or option awards in covered fiscal year prior to vesting date.</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="dei_DocumentType_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Document Type</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="fgen_ThirdPeoMember_lbl" xlink:role="http://www.xbrl.org/2003/role/verboseLabel">Third PEO [Member]</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="fgen_ThirdPeoMember_lbl" xlink:role="http://www.xbrl.org/2003/role/label">Third Peo Member</link:label>
          <link:label xml:lang="en-US" xlink:type="resource" xlink:label="fgen_ThirdPeoMember_lbl" xlink:role="http://www.xbrl.org/2003/role/documentation">Third Peo.</link:label>
          <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="fgen_FairValueAsOfVestingDateOfEquityAwardsGrantedAndVestedInSameCoveredFiscalYearMember" xlink:to="fgen_FairValueAsOfVestingDateOfEquityAwardsGrantedAndVestedInSameCoveredFiscalYearMember_lbl"/>
          <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="fgen_CompActuallyPaidAndTotalRevenueTextBlock" xlink:to="fgen_CompActuallyPaidAndTotalRevenueTextBlock_lbl"/>
          <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="fgen_ChangeInFairValueOfOutstandingAndUnvestedEquityAwardsGrantedInPriorFiscalYearsThatVestedInCoveredFiscalYearMember" xlink:to="fgen_ChangeInFairValueOfOutstandingAndUnvestedEquityAwardsGrantedInPriorFiscalYearsThatVestedInCoveredFiscalYearMember_lbl"/>
          <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_EntityCentralIndexKey" xlink:to="dei_EntityCentralIndexKey_lbl"/>
          <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_EntityRegistrantName" xlink:to="dei_EntityRegistrantName_lbl"/>
          <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="fgen_SecondPeoMember" xlink:to="fgen_SecondPeoMember_lbl"/>
          <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="fgen_FirstPeoMember" xlink:to="fgen_FirstPeoMember_lbl"/>
          <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="fgen_ChangeInFairValueOfOutstandingAndUnvestedEquityAwardsGrantedPriorFiscalYearsAsOfEndOfCoveredFiscalYearMember" xlink:to="fgen_ChangeInFairValueOfOutstandingAndUnvestedEquityAwardsGrantedPriorFiscalYearsAsOfEndOfCoveredFiscalYearMember_lbl"/>
          <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="fgen_CompActuallyPaidVsRevenueTextBlock" xlink:to="fgen_CompActuallyPaidVsRevenueTextBlock_lbl"/>
          <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="fgen_FairValueOutstandIngAndUnvestedEquityAwardsGrantedInPriorFiscalYearsFailedToMeetVestingConditionsMember" xlink:to="fgen_FairValueOutstandIngAndUnvestedEquityAwardsGrantedInPriorFiscalYearsFailedToMeetVestingConditionsMember_lbl"/>
          <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="fgen_FairValueOfAllOutstandingAndUnvestedEquityAwardsGrantedMember" xlink:to="fgen_FairValueOfAllOutstandingAndUnvestedEquityAwardsGrantedMember_lbl"/>
          <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_CoverAbstract" xlink:to="dei_CoverAbstract_lbl"/>
          <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_AmendmentFlag" xlink:to="dei_AmendmentFlag_lbl"/>
          <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="fgen_DollarValueOfDividendsOrOtherEarningsPaidOnStockOrOptionAwardsInCoveredFiscalYearPriorToVestingDateMember" xlink:to="fgen_DollarValueOfDividendsOrOtherEarningsPaidOnStockOrOptionAwardsInCoveredFiscalYearPriorToVestingDateMember_lbl"/>
          <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="dei_DocumentType" xlink:to="dei_DocumentType_lbl"/>
          <link:labelArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="fgen_ThirdPeoMember" xlink:to="fgen_ThirdPeoMember_lbl"/>
        </link:labelLink>
        <link:presentationLink xlink:role="http://www.fibrogen.com/20240424/taxonomy/role/DocumentDocumentAndEntityInformation" xlink:title="presentationLink" xlink:type="extended">
          <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_CoverAbstract" xlink:label="dei_CoverAbstract"/>
          <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_DocumentType" xlink:label="dei_DocumentType"/>
          <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityRegistrantName" xlink:label="dei_EntityRegistrantName"/>
          <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityCentralIndexKey" xlink:label="dei_EntityCentralIndexKey"/>
          <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_AmendmentFlag" xlink:label="dei_AmendmentFlag"/>
          <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="dei_CoverAbstract" xlink:to="dei_DocumentType" order="49.0" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/label"/>
          <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="dei_CoverAbstract" xlink:to="dei_EntityRegistrantName" order="50.0" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/label"/>
          <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="dei_CoverAbstract" xlink:to="dei_EntityCentralIndexKey" order="51.0" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/label"/>
          <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="dei_CoverAbstract" xlink:to="dei_AmendmentFlag" order="52.0" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/label"/>
        </link:presentationLink>
        <link:presentationLink xlink:role="http://xbrl.sec.gov/ecd/role/PvpDisclosure" xlink:title="presentationLink" xlink:type="extended">
          <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#ecd_AllAdjToCompMember" xlink:label="ecd_AllAdjToCompMember"/>
          <link:loc xlink:type="locator" xlink:href="fgen-20240424.xsd#fgen_FairValueOfAllOutstandingAndUnvestedEquityAwardsGrantedMember" xlink:label="fgen_FairValueOfAllOutstandingAndUnvestedEquityAwardsGrantedMember"/>
          <link:loc xlink:type="locator" xlink:href="fgen-20240424.xsd#fgen_ChangeInFairValueOfOutstandingAndUnvestedEquityAwardsGrantedPriorFiscalYearsAsOfEndOfCoveredFiscalYearMember" xlink:label="fgen_ChangeInFairValueOfOutstandingAndUnvestedEquityAwardsGrantedPriorFiscalYearsAsOfEndOfCoveredFiscalYearMember"/>
          <link:loc xlink:type="locator" xlink:href="fgen-20240424.xsd#fgen_FairValueAsOfVestingDateOfEquityAwardsGrantedAndVestedInSameCoveredFiscalYearMember" xlink:label="fgen_FairValueAsOfVestingDateOfEquityAwardsGrantedAndVestedInSameCoveredFiscalYearMember"/>
          <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#ecd_AllIndividualsMember" xlink:label="ecd_AllIndividualsMember"/>
          <link:loc xlink:type="locator" xlink:href="fgen-20240424.xsd#fgen_FirstPeoMember" xlink:label="fgen_FirstPeoMember"/>
          <link:loc xlink:type="locator" xlink:href="fgen-20240424.xsd#fgen_ChangeInFairValueOfOutstandingAndUnvestedEquityAwardsGrantedInPriorFiscalYearsThatVestedInCoveredFiscalYearMember" xlink:label="fgen_ChangeInFairValueOfOutstandingAndUnvestedEquityAwardsGrantedInPriorFiscalYearsThatVestedInCoveredFiscalYearMember"/>
          <link:loc xlink:type="locator" xlink:href="fgen-20240424.xsd#fgen_SecondPeoMember" xlink:label="fgen_SecondPeoMember"/>
          <link:loc xlink:type="locator" xlink:href="fgen-20240424.xsd#fgen_FairValueOutstandIngAndUnvestedEquityAwardsGrantedInPriorFiscalYearsFailedToMeetVestingConditionsMember" xlink:label="fgen_FairValueOutstandIngAndUnvestedEquityAwardsGrantedInPriorFiscalYearsFailedToMeetVestingConditionsMember"/>
          <link:loc xlink:type="locator" xlink:href="fgen-20240424.xsd#fgen_ThirdPeoMember" xlink:label="fgen_ThirdPeoMember"/>
          <link:loc xlink:type="locator" xlink:href="fgen-20240424.xsd#fgen_DollarValueOfDividendsOrOtherEarningsPaidOnStockOrOptionAwardsInCoveredFiscalYearPriorToVestingDateMember" xlink:label="fgen_DollarValueOfDividendsOrOtherEarningsPaidOnStockOrOptionAwardsInCoveredFiscalYearPriorToVestingDateMember"/>
          <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#ecd_PayVsPerformanceDisclosureLineItems" xlink:label="ecd_PayVsPerformanceDisclosureLineItems"/>
          <link:loc xlink:type="locator" xlink:href="fgen-20240424.xsd#fgen_CompActuallyPaidVsRevenueTextBlock" xlink:label="fgen_CompActuallyPaidVsRevenueTextBlock"/>
          <link:loc xlink:type="locator" xlink:href="fgen-20240424.xsd#fgen_CompActuallyPaidAndTotalRevenueTextBlock" xlink:label="fgen_CompActuallyPaidAndTotalRevenueTextBlock"/>
          <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ecd_AllAdjToCompMember" xlink:to="fgen_FairValueOfAllOutstandingAndUnvestedEquityAwardsGrantedMember" order="0" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
          <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ecd_AllAdjToCompMember" xlink:to="fgen_ChangeInFairValueOfOutstandingAndUnvestedEquityAwardsGrantedPriorFiscalYearsAsOfEndOfCoveredFiscalYearMember" order="1" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
          <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ecd_AllAdjToCompMember" xlink:to="fgen_FairValueAsOfVestingDateOfEquityAwardsGrantedAndVestedInSameCoveredFiscalYearMember" order="2" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/label"/>
          <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ecd_AllIndividualsMember" xlink:to="fgen_FirstPeoMember" order="2.0" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/label"/>
          <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ecd_AllAdjToCompMember" xlink:to="fgen_ChangeInFairValueOfOutstandingAndUnvestedEquityAwardsGrantedInPriorFiscalYearsThatVestedInCoveredFiscalYearMember" order="3" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/label"/>
          <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ecd_AllIndividualsMember" xlink:to="fgen_SecondPeoMember" order="3.0" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
          <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ecd_AllAdjToCompMember" xlink:to="fgen_FairValueOutstandIngAndUnvestedEquityAwardsGrantedInPriorFiscalYearsFailedToMeetVestingConditionsMember" order="4" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
          <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ecd_AllIndividualsMember" xlink:to="fgen_ThirdPeoMember" order="4.0" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
          <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ecd_AllAdjToCompMember" xlink:to="fgen_DollarValueOfDividendsOrOtherEarningsPaidOnStockOrOptionAwardsInCoveredFiscalYearPriorToVestingDateMember" order="5" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
          <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ecd_PayVsPerformanceDisclosureLineItems" xlink:to="fgen_CompActuallyPaidVsRevenueTextBlock" order="30.0" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
          <link:presentationArc xlink:type="arc" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="ecd_PayVsPerformanceDisclosureLineItems" xlink:to="fgen_CompActuallyPaidAndTotalRevenueTextBlock" order="31.0" priority="2" use="optional" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
        </link:presentationLink>
        <link:definitionLink xlink:type="extended" xlink:role="http://xbrl.sec.gov/ecd/role/PvpAdjustmentsOnly">
          <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#ecd_AllAdjToCompMember" xlink:label="ecd_AllAdjToCompMember"/>
          <link:loc xlink:type="locator" xlink:href="fgen-20240424.xsd#fgen_FairValueOfAllOutstandingAndUnvestedEquityAwardsGrantedMember" xlink:label="fgen_FairValueOfAllOutstandingAndUnvestedEquityAwardsGrantedMember"/>
          <link:loc xlink:type="locator" xlink:href="fgen-20240424.xsd#fgen_ChangeInFairValueOfOutstandingAndUnvestedEquityAwardsGrantedPriorFiscalYearsAsOfEndOfCoveredFiscalYearMember" xlink:label="fgen_ChangeInFairValueOfOutstandingAndUnvestedEquityAwardsGrantedPriorFiscalYearsAsOfEndOfCoveredFiscalYearMember"/>
          <link:loc xlink:type="locator" xlink:href="fgen-20240424.xsd#fgen_FairValueAsOfVestingDateOfEquityAwardsGrantedAndVestedInSameCoveredFiscalYearMember" xlink:label="fgen_FairValueAsOfVestingDateOfEquityAwardsGrantedAndVestedInSameCoveredFiscalYearMember"/>
          <link:loc xlink:type="locator" xlink:href="fgen-20240424.xsd#fgen_ChangeInFairValueOfOutstandingAndUnvestedEquityAwardsGrantedInPriorFiscalYearsThatVestedInCoveredFiscalYearMember" xlink:label="fgen_ChangeInFairValueOfOutstandingAndUnvestedEquityAwardsGrantedInPriorFiscalYearsThatVestedInCoveredFiscalYearMember"/>
          <link:loc xlink:type="locator" xlink:href="fgen-20240424.xsd#fgen_FairValueOutstandIngAndUnvestedEquityAwardsGrantedInPriorFiscalYearsFailedToMeetVestingConditionsMember" xlink:label="fgen_FairValueOutstandIngAndUnvestedEquityAwardsGrantedInPriorFiscalYearsFailedToMeetVestingConditionsMember"/>
          <link:loc xlink:type="locator" xlink:href="fgen-20240424.xsd#fgen_DollarValueOfDividendsOrOtherEarningsPaidOnStockOrOptionAwardsInCoveredFiscalYearPriorToVestingDateMember" xlink:label="fgen_DollarValueOfDividendsOrOtherEarningsPaidOnStockOrOptionAwardsInCoveredFiscalYearPriorToVestingDateMember"/>
          <link:definitionArc xlink:type="arc" order="0" xbrldt:closed="false" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ecd_AllAdjToCompMember" xlink:to="fgen_FairValueOfAllOutstandingAndUnvestedEquityAwardsGrantedMember" priority="2" use="optional"/>
          <link:definitionArc xlink:type="arc" order="1" xbrldt:closed="false" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ecd_AllAdjToCompMember" xlink:to="fgen_ChangeInFairValueOfOutstandingAndUnvestedEquityAwardsGrantedPriorFiscalYearsAsOfEndOfCoveredFiscalYearMember" priority="2" use="optional"/>
          <link:definitionArc xlink:type="arc" order="2" xbrldt:closed="false" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ecd_AllAdjToCompMember" xlink:to="fgen_FairValueAsOfVestingDateOfEquityAwardsGrantedAndVestedInSameCoveredFiscalYearMember" priority="2" use="optional"/>
          <link:definitionArc xlink:type="arc" order="3" xbrldt:closed="false" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ecd_AllAdjToCompMember" xlink:to="fgen_ChangeInFairValueOfOutstandingAndUnvestedEquityAwardsGrantedInPriorFiscalYearsThatVestedInCoveredFiscalYearMember" priority="2" use="optional"/>
          <link:definitionArc xlink:type="arc" order="4" xbrldt:closed="false" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ecd_AllAdjToCompMember" xlink:to="fgen_FairValueOutstandIngAndUnvestedEquityAwardsGrantedInPriorFiscalYearsFailedToMeetVestingConditionsMember" priority="2" use="optional"/>
          <link:definitionArc xlink:type="arc" order="5" xbrldt:closed="false" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ecd_AllAdjToCompMember" xlink:to="fgen_DollarValueOfDividendsOrOtherEarningsPaidOnStockOrOptionAwardsInCoveredFiscalYearPriorToVestingDateMember" priority="2" use="optional"/>
        </link:definitionLink>
        <link:definitionLink xlink:type="extended" xlink:role="http://xbrl.sec.gov/ecd/role/IndividualsOnly">
          <link:loc xlink:type="locator" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#ecd_AllIndividualsMember" xlink:label="ecd_AllIndividualsMember"/>
          <link:loc xlink:type="locator" xlink:href="fgen-20240424.xsd#fgen_FirstPeoMember" xlink:label="fgen_FirstPeoMember"/>
          <link:loc xlink:type="locator" xlink:href="fgen-20240424.xsd#fgen_SecondPeoMember" xlink:label="fgen_SecondPeoMember"/>
          <link:loc xlink:type="locator" xlink:href="fgen-20240424.xsd#fgen_ThirdPeoMember" xlink:label="fgen_ThirdPeoMember"/>
          <link:definitionArc xlink:type="arc" order="0" xbrldt:closed="false" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ecd_AllIndividualsMember" xlink:to="fgen_FirstPeoMember" priority="2" use="optional"/>
          <link:definitionArc xlink:type="arc" order="1" xbrldt:closed="false" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ecd_AllIndividualsMember" xlink:to="fgen_SecondPeoMember" priority="2" use="optional"/>
          <link:definitionArc xlink:type="arc" order="2" xbrldt:closed="false" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ecd_AllIndividualsMember" xlink:to="fgen_ThirdPeoMember" priority="2" use="optional"/>
        </link:definitionLink>
      </link:linkbase>
    </xsd:appinfo>
  </xsd:annotation>
  <xsd:element id="fgen_FairValueAsOfVestingDateOfEquityAwardsGrantedAndVestedInSameCoveredFiscalYearMember" name="FairValueAsOfVestingDateOfEquityAwardsGrantedAndVestedInSameCoveredFiscalYearMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="fgen_FirstPeoMember" name="FirstPeoMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="fgen_CompActuallyPaidVsRevenueTextBlock" name="CompActuallyPaidVsRevenueTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="fgen_SecondPeoMember" name="SecondPeoMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="fgen_FairValueOutstandIngAndUnvestedEquityAwardsGrantedInPriorFiscalYearsFailedToMeetVestingConditionsMember" name="FairValueOutstandIngAndUnvestedEquityAwardsGrantedInPriorFiscalYearsFailedToMeetVestingConditionsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="fgen_DollarValueOfDividendsOrOtherEarningsPaidOnStockOrOptionAwardsInCoveredFiscalYearPriorToVestingDateMember" name="DollarValueOfDividendsOrOtherEarningsPaidOnStockOrOptionAwardsInCoveredFiscalYearPriorToVestingDateMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="fgen_ChangeInFairValueOfOutstandingAndUnvestedEquityAwardsGrantedPriorFiscalYearsAsOfEndOfCoveredFiscalYearMember" name="ChangeInFairValueOfOutstandingAndUnvestedEquityAwardsGrantedPriorFiscalYearsAsOfEndOfCoveredFiscalYearMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="fgen_ThirdPeoMember" name="ThirdPeoMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="fgen_CompActuallyPaidAndTotalRevenueTextBlock" name="CompActuallyPaidAndTotalRevenueTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false"/>
  <xsd:element id="fgen_FairValueOfAllOutstandingAndUnvestedEquityAwardsGrantedMember" name="FairValueOfAllOutstandingAndUnvestedEquityAwardsGrantedMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
  <xsd:element id="fgen_ChangeInFairValueOfOutstandingAndUnvestedEquityAwardsGrantedInPriorFiscalYearsThatVestedInCoveredFiscalYearMember" name="ChangeInFairValueOfOutstandingAndUnvestedEquityAwardsGrantedInPriorFiscalYearsThatVestedInCoveredFiscalYearMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true"/>
</xsd:schema>
