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Collaboration Agreements, License Agreement and Revenues - AstraZeneca Agreements - Additional Information 1 (Detail) - USD ($) $ in Thousands |  | 12 Months Ended |
--- | --- | --- | ---
Jul. 30, 2013 | Dec. 31, 2024 | Dec. 31, 2023 | Sep. 18, 2023
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |
Total revenue |  | $ 29,621 | $ 46,803 |
Drug Product Revenue, Net [Member] |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |
Total revenue |  | 27,673 | 18,753 |
AstraZeneca Agreements [Member] |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |
Total revenue |  | 159,000 | 89,100 |
AstraZeneca Agreements [Member] | U.S./RoW [Member] |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |
Aggregate considerations received |  | 439,000 |  |
AstraZeneca Agreements [Member] | China [Member] |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |
Potential milestone payments | $ 348,500 |  |  |
Transaction price and allocated to performance obligations |  |  |  | $ 4,000
Proceeds from upfront, non-contingent and non-refundable payments | 28,200 |  |  |
Commercial sales and other events milestone | 187,500 |  |  |
Aggregate considerations received |  | 81,200 |  |
Recognized as Revenue |  |  | 3,500 |
Contract asset |  | $ 4,000 | $ 4,000 |
AstraZeneca Agreements [Member] | China [Member] | Clinical and Development Milestone [Member] |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |
Potential milestone payments | 15,000 |  |  |
AstraZeneca Agreements [Member] | China [Member] | Regulatory Milestone [Member] |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |
Potential milestone payments | $ 146,000 |  |  |

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