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Liability Related to Sale of Future Revenues - Additional Information (Detail) - USD ($) | 1 Months Ended | 12 Months Ended
--- | --- | ---
Nov. 30, 2022 | Dec. 31, 2024 | Dec. 31, 2023
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Total revenue |  | $ 29,621,000 | $ 46,803,000
Interest paid |  | (5,653,000) |
Drug Product Revenue [Member] |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Total revenue |  | $ 27,673,000 | 18,753,000
NovaQuest Capital Management [Member] | Revenue Interest Financing Agreement [Member] |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Effective annual interest rate related to sale of future revenues |  | 15.60% |
NovaQuest Capital Management [Member] | Payment Cap Date on or before December 31, 2028 [Member] | Revenue Interest Financing Agreement [Member] |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Maximum payment cap amount | $ 100,000,000 |  |
NovaQuest Capital Management [Member] | Payment Cap Date on or after January 1, 2029 [Member] | Revenue Interest Financing Agreement [Member] |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Maximum payment cap amount | 112,500,000 |  |
NovaQuest Capital Management [Member] | Payment Cap Date after January 1, 2030 [Member] | Revenue Interest Financing Agreement [Member] |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Maximum payment cap amount | 125,000,000 |  |
Minimum [Member] | NovaQuest Capital Management [Member] | Revenue Interest Financing Agreement [Member] |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Prepayment amount of 2024 to 2030 | 80,000,000 |  |
Minimum [Member] | NovaQuest Capital Management [Member] | Payment Period One [Member] | Revenue Interest Financing Agreement [Member] |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Revenue interest payment | 62,500,000 |  |
Minimum [Member] | NovaQuest Capital Management [Member] | Payment Period Two [Member] | Revenue Interest Financing Agreement [Member] |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Revenue interest payment | 125,000,000 |  |
Maximum [Member] | NovaQuest Capital Management [Member] | Revenue Interest Financing Agreement [Member] |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Prepayment amount of 2024 to 2030 | 125,000,000 |  |
Product [Member] | NovaQuest Capital Management [Member] | Revenue Interest Financing Agreement [Member] |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Revenue interest payment | 10,000,000 |  |
License [Member] |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Total revenue |  | $ 0 | 9,649,000
Other Revenue - Contract Manufacturing [Member] |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Total revenue |  | 1,948,000 | 18,401,000
Astellas Agreement [Member] |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Future revenue granted | $ 50,000,000 |  |
Percentage of revenue interest on global net sales | 100.00% |  |
Astellas Agreement [Member] | Drug Product Revenue [Member] |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Total revenue |  | 2,000,000 | 18,800,000
Non-cash interest expense related to drug product revenue |  | 7,900,000 | 7,700,000
Astellas Agreement [Member] | Development Revenue [Member] |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Total revenue |  | 1,400,000 | $ 6,700,000
Astellas Agreement [Member] | Maximum [Member] |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Revenue payment cap amount |  | $ 125,000,000 |
Astellas Agreement [Member] | Product [Member] |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Percentage of revenue sold | 22.50% |  |
Astellas Agreement [Member] | Milestone payments [Member] |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Percentage of revenue sold | 10.00% |  |
Astellas Agreement [Member] | Milestone payments [Member] | Payment Period One [Member] |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |
Percentage of revenue sold | 20.00% |  |

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