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v3.25.1

Collaboration Agreements, License Agreement and Revenues - Drug Product Revenue - Additional Information (Detail) - USD ($) $ in Thousands | 3 Months Ended | 12 Months Ended
--- | --- | ---
Dec. 31, 2024 | Mar. 31, 2024 | Dec. 31, 2023 | Jun. 30, 2023 | Dec. 31, 2024 | Dec. 31, 2023
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Drug product revenue recognized |  |  |  |  | $ 29,621 | $ 46,803
Deferred Revenue | $ 27,290 |  | $ 12,740 |  | 27,290 | 12,740
Related cost of goods sold |  |  |  |  | 15,561 | 3,962
Other long-term liabilities | 822 |  | 2,858 |  | 822 | 2,858
AstraZeneca U.S./RoW Agreement [Member] |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Accrued liabilities |  |  | 11,200 |  |  | 11,200
Related cost of goods sold |  | $ 21,100 |  |  |  |
Cumulative catch-up net adjustment |  | $ 25,700 |  |  |  |
Astra Zeneca Agreements [Member] |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Drug product revenue recognized |  |  |  |  | 159,000 | 89,100
Drug Product Revenue, Net [Member] |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Drug product revenue recognized |  |  |  |  | 27,673 | 18,753
Drug Product Revenue, Net [Member] | API Shipment [Member] |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Drug product revenue recognized |  |  |  |  | 2,900 | 1,300
Drug Product Revenue, Net [Member] | Astellas Agreement [Member] |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Drug product revenue recognized |  |  |  |  | 2,000 | 18,800
Drug Product Revenue, Net [Member] | Japan [Member] |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Drug product revenue recognized |  |  |  | $ 14,400 |  |
Drug Product Revenue, Net [Member] | Japan [Member] | Astellas Agreement [Member] |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Drug product revenue recognized |  |  |  |  | (2,872) | 15,656
Accrued liabilities | 2,500 |  | 1,200 |  | 2,500 | 1,200
Other long-term liabilities | 600 |  | 700 |  | 600 | 700
Drug Product Revenue, Net [Member] | Europe [Member] | Astellas Agreement [Member] |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Drug product revenue recognized |  |  |  |  | 4,874 | 3,097
Drug Product Revenue, Net [Member] | Europe [Member] | Astellas Europe Agreement [Member] |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Burdened manufacturing costs | 600 |  | 800 |  |  |
Bulk Drug Product [Member] | Astellas Europe Agreement [Member] |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Deferred Revenue | 4,400 |  | 17,700 |  | 4,400 | 17,700
Bulk Drug Product [Member] | Europe [Member] | Astellas Europe Agreement [Member] |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Drug product revenue recognized |  |  |  |  | 7,200 | 38,700
Collaboration agreement payment |  |  |  |  | 35,300 |
Accrued liabilities | $ 10,500 |  | $ 38,600 |  | 10,500 | 38,600
Bulk Drug Product [Member] | Europe [Member] | Astellas Europe Agreement [Member] | Royalty Revenue [Member] |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Royalty revenue recognized as drug product revenue |  |  |  |  | $ 4,300 | $ 2,300

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