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Income Taxes (Tables)

12 Months Ended

Dec. 31, 2024

Income Tax Disclosure [Abstract]

Schedule of Components of Loss Before Income Taxes

The components of loss before income taxes are as follows (in thousands):

		Years Ended December 31,
		2024				2023
Domestic		$	(142,819	)		$	(324,581	)
Foreign			(10,548	)			1,359
Loss before provision for income taxes		$	(153,367	)		$	(323,222	)

Schedule of Components of Provision For Income Taxes

The provision for income taxes consists of the following (in thousands):

		Years Ended December 31,
		2024				2023
Current:
Federal		$	—			$	—
State			—				—
Foreign			(269	)			(252	)
Total current			(269	)			(252	)
Deferred:
Federal			—				—
State			—				—
Foreign			—				—
Total deferred			—				—
Benefit from income taxes		$	(269	)		$	(252	)

Schedule of Reconciliation Between Statutory Federal Income Tax Rate and Effective Tax Rate

The following is the reconciliation between the statutory federal income tax rate and the Company’s effective tax rate:

	Years Ended December 31,
	2024				2023
Tax at statutory federal rate		21.0	%			21.0	%
State tax		—	%			—	%
Stock-based compensation expense		(3.2	)%			(1.0	)%
Net operating losses not benefitted		(13.9	)%			(15.6	)%
Foreign net operating losses not benefitted		(1.4	)%			0.1	%
Deduction limitation on executive compensation		—	%			(0.4	)%
Global intangible low-taxed income		(2.1	)%			(3.8	)%
Other		(0.2	)%			(0.2	)%
Total		0.2	%			0.1	%

Schedule of Significant Components of Deferred Tax Assets

Significant components of the Company’s deferred tax assets are as follows (in thousands):

		December 31,
		2024				2023
Federal and state net operating loss carryforwards		$	206,365			$	175,258
Tax credit carryforwards			129,320				123,156
Foreign net operating loss carryforwards			120				157
Capitalized research and development expenses			83,329				81,697
Stock-based compensation			6,365				7,269
Lease obligations			22				16,508
Reserves and accruals			4,418				5,475
Deferred revenue			7,785				10,038
Intangible assets			15,036				16,517
Other			—				5
Subtotal			452,760				436,080
Less: Valuation allowance			(452,740	)			(426,355	)
Net deferred tax assets			20				9,725
Fixed assets			(20	)			(9,725	)
Non-deductible accrued expenses			—				—
Net deferred tax liabilities			(20	)			(9,725	)
Total net deferred tax assets		$	—			$	—

Schedule of Reconciliation of the Beginning and Ending Amounts of Unrecognized Income Tax Benefits

A reconciliation of the beginning and ending amounts of unrecognized income tax benefits during the two years ended December 31, 2024 is as follows (in thousands):

		Federal and State
Balance as of December 31, 2022		$	62,249
Decrease due to prior positions			(154	)
Increase due to current year position			8,805
Foreign exchange rate differential			(190	)
Balance as of December 31, 2023			70,710
Decrease due to prior positions			(156	)
Increase due to current year position			3,920
Foreign exchange rate differential			(153	)
Balance as of December 31, 2024		$	74,321

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