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Collaboration Agreements, License Agreement and Revenues - Astellas Agreements - Additional Information (Detail) - Astellas Agreement [Member] - USD ($)
$ in Millions
1 Months Ended 12 Months Ended 35 Months Ended 45 Months Ended
Apr. 30, 2006
Jun. 30, 2005
Dec. 31, 2024
Feb. 28, 2009
Feb. 28, 2009
Japan [Member]          
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]          
Upfront, non-contingent and time-based payments received         $ 40.1
Potential milestone payments   $ 132.5      
Commercial sales milestone   15.0      
Additional consideration based on net sales description     the low 20% range of the list price    
Aggregate considerations received excluding drug product revenue     $ 105.1    
Japan [Member] | Clinical and Development Milestone [Member]          
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]          
Potential milestone payments   22.5      
Japan [Member] | Regulatory Milestone [Member]          
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]          
Potential milestone payments   $ 95.0      
Europe [Member]          
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]          
Upfront, non-contingent and time-based payments received       $ 320.0  
Additional consideration based on net sales description     low 20% range    
Aggregate considerations received excluding drug product revenue     $ 685.0    
Development and regulatory approval milestones $ 425.0        
Percentage of joint development costs committed to fund 50.00%        
Europe [Member] | Clinical and Development Milestone [Member]          
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]          
Potential milestone payments $ 90.0        
Europe [Member] | Regulatory Milestone [Member]          
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]          
Potential milestone payments $ 335.0