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Collaboration Agreements, License Agreement and Revenues - Summary of License Revenue and Development Revenue Recognized under Agreement (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023
Disaggregation of Revenue [Line Items]
Total revenue	$ 29,621	$ 46,803
License Revenue [Member]
Disaggregation of Revenue [Line Items]
Total revenue	0	9,649
Development Revenue [Member]
Disaggregation of Revenue [Line Items]
Total revenue	1,948	18,401
Astellas Agreement [Member] | License Revenue [Member] | Europe [Member]
Disaggregation of Revenue [Line Items]
Total revenue	1,395	6,452
AstraZeneca Agreements [Member]
Disaggregation of Revenue [Line Items]
Total revenue	159,000	89,100
AstraZeneca Agreements [Member] | License Revenue [Member] | U.S./RoW and China [Member]
Disaggregation of Revenue [Line Items]
Total revenue	0	2,649
AstraZeneca Agreements [Member] | Development Revenue [Member] | U.S./RoW and China [Member]
Disaggregation of Revenue [Line Items]
Total revenue	$ 418	$ 9,473

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