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Collaboration Agreements, License Agreement and Revenues - Product Revenue, Net - Additional Information 1 (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Total revenue	$ 29,621	$ 46,803
AstraZeneca Agreements [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Total revenue	159,000	89,100
Contract with Customer, Liability [Abstract]
Deferred Revenue	132,097	179,851
AstraZeneca Agreements [Member] | China [Member]
Contract with Customer, Liability [Abstract]
Deferred Revenue	$ 19,900
Recognized as Revenue		$ 3,500

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