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Collaboration Agreements, License Agreement and Revenues - Roll-forward of Related Contract Liabilities (Detail) $ in Thousands	12 Months Ended
	Dec. 31, 2024 USD ($)
AstraZeneca Agreements [Member]
Contract with Customer Liability [Line Items]
Balance at December 31, 2023	$ (179,851)
Additions	(112,503)
Currency Translation and Other	1,247
Recognized as Revenue (Discontinued Operations)	159,010
Balance at December 31, 2024	(132,097)
Drug Product Revenue, Net [Member] | Astellas Agreement [Member] | Europe [Member]
Contract with Customer Liability [Line Items]
Balance at December 31, 2023	(16,925)
Additions	(4,441)
Recognized as Revenue	4,295
Reclassified to accrued liability / accounts payable	7,170
Balance at December 31, 2024	$ (9,901)

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- Definition

Contract with customer liability additions.

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- Definition

Amount of obligation to transfer good or service to customer for which consideration has been received or is receivable.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 606
-SubTopic 10
-Name Accounting Standards Codification
-Section 45
-Paragraph 1
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Amount of revenue recognized that was previously included in balance of obligation to transfer good or service to customer for which consideration from customer has been received or is due.

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Amount of revenue attributable to disposal group, including, but not limited to, discontinued operation.

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Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 205
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