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Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2024
Dec. 31, 2023
Operating activities    
Net loss $ (47,579) $ (284,232)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation 2,654 9,518
Amortization of finance lease right-of-use assets 38 412
Net accretion of premium and discount on investments (1,680) (5,061)
Investment income in unconsolidated variable interest entity (3,969) (2,638)
Loss on disposal of property and equipment 2,551 4
Stock-based compensation 25,215 50,767
Acquired in-process research and development expenses 0 24,636
Non-cash interest expense related to sale of future revenues 0 7,734
Dividend received from unconsolidated variable interest entity 2,230 2,255
Impairment of investment 0 1,000
Realized loss on sales of available-for-sale securities 0 271
Changes in operating assets and liabilities:    
Accounts receivable, net (6,737) 3,433
Inventories 22,284 (1,695)
Prepaid expenses and other current assets (15,550) (28,165)
Operating lease right-of-use assets 66,306 11,704
Other assets 1,010 256
Accounts payable 14,512 (15,514)
Accrued and other liabilities (93,790) (49,778)
Operating lease liabilities, current (12,774) 3,820
Deferred revenues (28,297) (28,166)
Accrued interest expense related to sale of future revenues 2,257 0
Accrued interest for finance lease liabilities 14 (11)
Operating lease liabilities, non-current (66,154) (12,998)
Other long-term liabilities (540) (2,573)
Net cash used in operating activities (137,999) (315,021)
Investing activities    
Purchases of property and equipment (266) (2,519)
Proceeds from sale of property and equipment 1,046 0
Purchases of available-for-sale securities (8,628) (251,830)
Cash acquired from consolidation of Fortis 0 656
Proceeds from sales of available-for-sale securities 0 6,729
Proceeds from maturities of investments 133,841 400,621
Net cash provided by investing activities 125,993 153,657
Financing activities    
Proceeds from senior secured term loan facilities, net of issuance costs 0 74,078
Cash paid for transaction costs for senior secured term loan facilities 0 (2,746)
Repayments of finance lease liabilities (40) (148)
Repayments of lease obligations 0 (336)
Cash paid for payroll taxes on restricted stock unit releases (354) (237)
Proceeds from issuance of common stock under ATM Program, net of commissions 0 48,407
Proceeds from issuance of common stock under employee stock plans 139 3,731
Net cash (used in) provided by financing activities (255) 122,749
Effect of exchange rate change on cash and cash equivalents 751 (3,397)
Net increase (decrease) in cash and cash equivalents (11,510) (42,012)
Total cash and cash equivalents at beginning of period 113,688 155,700
Total cash and cash equivalents at end of period 102,178 113,688
Supplemental Cash Flow Information [Abstract]    
Non cash acquisition in Fortis 0 (22,000)
Interest payments 16,207 6,383
Balance in accounts payable and accrued liabilities related to purchases of property and equipment 0 103
Reconciliation of cash and cash equivalents to the consolidated balance sheets:    
Cash and cash equivalents of continuing operations 50,482 81,553
Cash and cash equivalents included in assets held for sale 51,696 32,135
Total cash and cash equivalents in the consolidated statements of cash flows $ 102,178 $ 113,688