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Liability Related to Sale of Future Revenues - Additional Information (Detail) - USD ($)
 1 Months Ended 12 Months Ended
Nov. 30, 2022
Dec. 31, 2024
Dec. 31, 2023
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]      
Total revenue   $ 29,621,000 $ 46,803,000
Interest paid   (5,653,000)  
Drug Product Revenue [Member]      
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]      
Total revenue   $ 27,673,000 18,753,000
NovaQuest Capital Management [Member] | Revenue Interest Financing Agreement [Member]      
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]      
Effective annual interest rate related to sale of future revenues   15.60%  
NovaQuest Capital Management [Member] | Payment Cap Date on or before December 31, 2028 [Member] | Revenue Interest Financing Agreement [Member]      
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]      
Maximum payment cap amount $ 100,000,000    
NovaQuest Capital Management [Member] | Payment Cap Date on or after January 1, 2029 [Member] | Revenue Interest Financing Agreement [Member]      
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]      
Maximum payment cap amount 112,500,000    
NovaQuest Capital Management [Member] | Payment Cap Date after January 1, 2030 [Member] | Revenue Interest Financing Agreement [Member]      
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]      
Maximum payment cap amount 125,000,000    
Minimum [Member] | NovaQuest Capital Management [Member] | Revenue Interest Financing Agreement [Member]      
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]      
Prepayment amount of 2024 to 2030 80,000,000    
Minimum [Member] | NovaQuest Capital Management [Member] | Payment Period One [Member] | Revenue Interest Financing Agreement [Member]      
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]      
Revenue interest payment 62,500,000    
Minimum [Member] | NovaQuest Capital Management [Member] | Payment Period Two [Member] | Revenue Interest Financing Agreement [Member]      
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]      
Revenue interest payment 125,000,000    
Maximum [Member] | NovaQuest Capital Management [Member] | Revenue Interest Financing Agreement [Member]      
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]      
Prepayment amount of 2024 to 2030 125,000,000    
Product [Member] | NovaQuest Capital Management [Member] | Revenue Interest Financing Agreement [Member]      
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]      
Revenue interest payment 10,000,000    
License [Member]      
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]      
Total revenue   $ 0 9,649,000
Other Revenue - Contract Manufacturing [Member]      
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]      
Total revenue   1,948,000 18,401,000
Astellas Agreement [Member]      
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]      
Future revenue granted $ 50,000,000    
Percentage of revenue interest on global net sales 100.00%    
Astellas Agreement [Member] | Drug Product Revenue [Member]      
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]      
Total revenue   2,000,000 18,800,000
Non-cash interest expense related to drug product revenue   7,900,000 7,700,000
Astellas Agreement [Member] | Development Revenue [Member]      
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]      
Total revenue   1,400,000 $ 6,700,000
Astellas Agreement [Member] | Maximum [Member]      
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]      
Revenue payment cap amount   $ 125,000,000  
Astellas Agreement [Member] | Product [Member]      
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]      
Percentage of revenue sold 22.50%    
Astellas Agreement [Member] | Milestone payments [Member]      
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]      
Percentage of revenue sold 10.00%    
Astellas Agreement [Member] | Milestone payments [Member] | Payment Period One [Member]      
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]      
Percentage of revenue sold 20.00%