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v3.25.1

Collaboration Agreements, License Agreement and Revenues - Drug Product Revenue - Additional Information (Detail) - USD ($) $ in Thousands | 3 Months Ended | 12 Months Ended
--- | --- | ---
Mar. 31, 2025 | Dec. 31, 2024 | Mar. 31, 2024 | Dec. 31, 2024
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |
Deferred Revenue | $ 22,509 | $ 27,290 |  | $ 27,290
Drug product revenue recognized | 2,739 |  | $ 25,364 |
Other long-term liabilities | 830 | 822 |  | 822
Astra Zeneca Agreements [Member] |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |
Drug product revenue recognized | 36,900 |  | 27,100 |
Drug Product Revenue, Net [Member] |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |
Drug product revenue recognized | 2,595 |  | 24,486 |
Drug Product Revenue, Net [Member] | Astellas Agreement [Member] |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |
Drug product revenue recognized | 2,600 |  | (1,200) |
Drug Product Revenue, Net [Member] | Europe [Member] | Astellas Agreement [Member] |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |
Drug product revenue recognized | 814 |  | 1,021 |
Drug Product Revenue, Net [Member] | Europe [Member] | Astellas Europe Agreement [Member] |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |
Drug product revenue recognized | 2,100 |  |  |
Burdened manufacturing costs |  | 600 |  |
Drug Product Revenue, Net [Member] | Japan [Member] | Astellas Agreement [Member] |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |
Drug product revenue recognized | 1,781 |  | (2,205) |
Accrued liabilities | 700 | 2,500 |  | 2,500
Other long-term liabilities | 600 | 600 |  | 600
Drug Product Revenue, Net [Member] | API Shipment [Member] |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |
Drug product revenue recognized | 1,800 |  | 2,200 |
Bulk Drug Product [Member] | Astellas Europe Agreement [Member] |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |
Deferred Revenue |  | 4,400 |  | 4,400
Bulk Drug Product [Member] | Europe [Member] | Astellas Europe Agreement [Member] |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |
Drug product revenue recognized |  |  |  | 7,200
Accrued liabilities | 12,600 | $ 10,500 |  | $ 10,500
Bulk Drug Product [Member] | Europe [Member] | Astellas Europe Agreement [Member] | Royalty Revenue [Member] |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |
Royalty revenue recognized as drug product revenue | $ 800 |  | $ 1,000 |

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