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Collaboration Agreements, License Agreement and Revenues - AstraZeneca U.S./RoW Agreement - Additional Information (Detail) - USD ($) $ in Thousands | 3 Months Ended
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Mar. 31, 2025 | Mar. 31, 2024
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |
Related cost of goods sold | $ 252 | $ 21,343
AstraZeneca U.S./RoW Agreement [Member] |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |
Cumulative catch-up net adjustment |  | 25,700
Related cost of goods sold |  | $ 21,100

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