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Collaboration Agreements, License Agreement and Revenues - Astellas Agreements - Additional Information (Detail) - USD ($)	1 Months Ended		3 Months Ended
	Apr. 30, 2006	Jun. 30, 2005	Mar. 31, 2025	Mar. 31, 2024	Dec. 31, 2024
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Total revenue			$ 2,739,000	$ 25,364,000
Deferred Revenue			22,509,000		$ 27,290,000
Drug Product Revenue, Net [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Total revenue			2,595,000	24,486,000
Japan [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Transaction price, variable consideration from estimated future co-development billing			0
Europe [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Transaction price, variable consideration from estimated future co-development billing			$ 0
Astellas Agreement [Member] | Japan [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Upfront, non-contingent and time-based payments received		$ 172,600,000
Additional consideration based on net sales description			the low 20% range of the list price
Aggregate consideration received excluding drug product revenue			$ 105,100,000
Transaction price, variable consideration from estimated future co-development billing			0	0
Changes in revenue from changes to estimated variable consideration			0
Astellas Agreement [Member] | Japan [Member] | License [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Cash Consideration Received Under Collaboration Agreement			100,300,000
Astellas Agreement [Member] | Japan [Member] | Co-development, information sharing & committee services [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Cash Consideration Received Under Collaboration Agreement			$ 17,100,000
Astellas Agreement [Member] | Europe [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Upfront, non-contingent and time-based payments received	$ 745,000,000
Additional consideration based on net sales description			low 20% range
Aggregate consideration received excluding drug product revenue			$ 685,000,000
Percentage of joint development costs committed to fund	50.00%
Changes in revenue from changes to estimated variable consideration			0
Astellas Agreement [Member] | Europe [Member] | License [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Total revenue			0	$ 0
Cash Consideration Received Under Collaboration Agreement			619,000,000
Astellas Agreement [Member] | Europe [Member] | Co-development, information sharing & committee services [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Cash Consideration Received Under Collaboration Agreement			$ 288,300,000

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Amount of obligation to transfer good or service to customer for which consideration has been received or is receivable, classified as current.

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