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Collaboration Agreements, License Agreement and Revenues - Roll-forward of Related Contract Liabilities (Detail) $ in Thousands	3 Months Ended
	Mar. 31, 2025 USD ($)
AstraZeneca Agreements [Member]
Contract with Customer Liability [Line Items]
Balance at December 31, 2024	$ (132,097)
Additions	(35,363)
Recognized as Revenue (Discontinued Operations)	36,863
Currency Translation and Other	(248)
Balance at March 31, 2025	(130,845)
Drug Product Revenue, Net [Member] | Astellas Agreement [Member] | Europe [Member]
Contract with Customer Liability [Line Items]
Balance at December 31, 2024	(9,901)
Recognized as Revenue	814
Reclassified to Accrued Liability / Accounts Payable	2,076
Balance at March 31, 2025	$ (7,011)

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- Definition

Contract with customer liability additions.

+ References

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- Definition

Contract with customer, liability, increase (decrease) from current translation and other.

+ References

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- Definition

Amount of obligation to transfer good or service to customer for which consideration has been received or is receivable.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 606
-SubTopic 10
-Name Accounting Standards Codification
-Section 45
-Paragraph 1
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147479837/606-10-45-1

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
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Reference 3: http://www.xbrl.org/2003/role/disclosureRef
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-Section 45
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Amount of revenue recognized that was previously included in balance of obligation to transfer good or service to customer for which consideration from customer has been received or is due.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
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- Definition

Amount of revenue attributable to disposal group, including, but not limited to, discontinued operation.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 205
-SubTopic 20
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-Section 50
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