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Collaboration Agreements, License Agreement and Revenues - AstraZeneca U.S./RoW Agreement - Additional Information (Detail) - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2025
Mar. 31, 2024
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]    
Related cost of goods sold $ 252 $ 21,343
AstraZeneca U.S./RoW Agreement [Member]    
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]    
Cumulative catch-up net adjustment   25,700
Related cost of goods sold   $ 21,100