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Collaboration Agreements, License Agreement and Revenues - AstraZeneca Agreements - Additional Information 1 (Detail) - USD ($) $ in Thousands |  | 3 Months Ended | 6 Months Ended
--- | --- | --- | ---
Jul. 30, 2013 | Jun. 30, 2025 | Jun. 30, 2024 | Jun. 30, 2025 | Jun. 30, 2024
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |
Total revenue |  | $ 1,348 | $ 998 | $ 4,088 | $ 26,363
AstraZeneca Agreements [Member] |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |
Total revenue |  | $ 16,400 | $ 46,000 | 53,300 | $ 73,100
AstraZeneca Agreements [Member] | U.S./RoW [Member] |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |
Aggregate considerations received |  |  |  | 439,000 |
AstraZeneca Agreements [Member] | China [Member] |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |
Upfront, non-contingent, non-refundable and time-based payments | $ 376,700 |  |  |  |
Aggregate considerations received |  |  |  | $ 81,200 |

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