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Collaboration Agreements, License Agreement and Revenues - AstraZeneca U.S./RoW Agreement - Additional Information (Detail) - USD ($) $ in Thousands	3 Months Ended			6 Months Ended
	Jun. 30, 2025	Jun. 30, 2024	Mar. 31, 2024	Jun. 30, 2025	Jun. 30, 2024
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Related cost of goods sold	$ 85	$ 140		$ 337	$ 21,483
AstraZeneca U.S./RoW Agreement [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Cumulative catch-up net adjustment			$ 25,700
Related cost of goods sold			$ 21,100

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