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Collaboration Agreements, License Agreement and Revenues - AstraZeneca U.S./RoW Agreement - Additional Information (Detail) - USD ($) $ in Thousands | 3 Months Ended | 9 Months Ended
--- | --- | ---
Sep. 30, 2025 | Sep. 30, 2024 | Mar. 31, 2024 | Sep. 30, 2025 | Sep. 30, 2024
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Related cost of goods sold | $ (58) | $ (75) |  | $ 278 | $ 21,407
AstraZeneca U.S./RoW Agreement [Member] |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Cumulative catch-up net adjustment |  |  | $ 25,700 |  |
Related cost of goods sold |  |  | $ 21,100 |  |

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