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Significant Accounting Policies - Summary of Potentially Dilutive Securities (Details) - shares
12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]      
Potentially dilutive securities not included in the calculation of diluted net loss per share 513,869 2,457,897 6,436,235
Preferred Redeemable And Convertible Stock, Including Accumulated Dividends      
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]      
Potentially dilutive securities not included in the calculation of diluted net loss per share   2,406,894 4,891,205
Employee Stock Options      
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]      
Potentially dilutive securities not included in the calculation of diluted net loss per share 513,869   756,692
Warrants outstanding      
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]      
Potentially dilutive securities not included in the calculation of diluted net loss per share   51,003  
Series G Preferred Stock | Warrants outstanding      
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]      
Potentially dilutive securities not included in the calculation of diluted net loss per share     788,338