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Collaboration Agreement - Related Party (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020
Related Party Transaction [Line Items]
Collaboration revenue - related party	$ 30,017	$ 9,934
Takeda | Investor | Collaborative Arrangement
Related Party Transaction [Line Items]
Proceeds from collaborators	3,600	$ 14,000
Collaboration revenue - related party	$ 82,000

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