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STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2023
Dec. 31, 2022
Cash flows from operations:    
Net loss $ (87,298) $ (101,945)
Adjustments to reconcile net loss to net cash used in operations:    
Stock-based compensation 6,939 6,462
Depreciation 4,042 3,073
Amortization of (discount) premium on debt securities (1,483) 1,370
Non-cash operating lease expense 364 302
Loss on sale of assets 303 704
Changes in operating assets and liabilities:    
Prepaid expenses and other current assets 10,458 (3,842)
Other assets 165 (53)
Accounts payable (5,629) (2,842)
Accrued expenses and other current liabilities (8,636) 2,975
Non-current operating lease liabilities (796) (702)
Deferred revenue 343 0
Net cash used in operating activities (81,228) (94,498)
Cash flows from investing activities:    
Sale and maturities of investments 190,999 193,325
Purchases of investments (79,733) (132,377)
Purchases of property and equipment (407) (11,614)
Sale of property and equipment 0 104
Net cash provided by investing activities 110,859 49,438
Cash flows from financing activities:    
Proceeds from sale of common stock and pre-funded warrants, net of issuance cost 48,170 0
Proceeds from the exercise of stock options and purchases of common stock pursuant to the employee stock purchase plan 499 171
Taxes paid related to net share settlement of equity awards (53) 0
Net cash provided by financing activities 48,616 171
Net increase (decrease) in cash and cash equivalents 78,247 (44,889)
Cash and cash equivalents, beginning of period 47,379 92,268
Cash and cash equivalents, end of period 125,626 47,379
Supplemental disclosures of non-cash investing and financing activities:    
Unpaid amounts for direct offering costs 339 0
Deferred offering cost paid in prior period 251 0
Unpaid amounts related to purchase of property and equipment 71 0
Operating lease liabilities recognized for operating right-of-use assets 0 5,447
Operating right-of-use assets exchanged for operating lease liabilities $ 0 $ 2,945