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Income Taxes (Operating Loss Carryforwards, Narrative) (Details) - USD ($) | 12 Months Ended
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Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2014
Charitable, Foreign Tax Credit and AMT Carryforward |  |  |
Operating Loss Carryforwards [Line Items] |  |  |
Recognized carryforward tax asset | $ 200,000 |  |
Orphan Drug and Research and Development Tax Credit |  |  |
Operating Loss Carryforwards [Line Items] |  |  |
Recognized carryforward tax asset | 1,200,000 |  |
Federal |  |  |
Operating Loss Carryforwards [Line Items] |  |  |
Operating loss carryforwards | 50,157,928 |  |
Federal | Exercise of NonQualified Stock Options |  |  |
Operating Loss Carryforwards [Line Items] |  |  |
Operating loss carryforwards | 44,100,000 |  |
State |  |  |
Operating Loss Carryforwards [Line Items] |  |  |
Operating loss carryforwards | 54,890,031 |  |
Operating loss carryforwards, amount subject to full valuation allowance | 4,200,000 |  |
State | Exercise of NonQualified Stock Options |  |  |
Operating Loss Carryforwards [Line Items] |  |  |
Operating loss carryforwards | 45,400,000 |  |
Valuation allowance for deferred tax assets: |  |  |
Operating Loss Carryforwards [Line Items] |  |  |
Charged to costs and expenses | $ 203,003 | $ 33,423 | $ 20,457

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