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Revenues (Narrative) (Details) - USD ($)
 12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Product Revenues      
Net product revenue $ 32,478,185 $ 33,013,184 $ 36,683,762
Accrued liabilities, current 6,755,652 9,534,268  
Other Revenues      
Other revenue, upfront payment 1,400,000    
Other revenue, potential upfront payments related to regulatory approval 1,700,000    
Other revenue, potential upfront payment related to product sales 4,700,000    
Cumulative upfront payment 1,500,000    
Revenue related to milestone payments 200,000    
Product Sales Related Accruals - Rebates, Product Returns, Administrative Fees and Service Fees      
Product Revenues      
Accrued liabilities, current 4,100,000 6,800,000  
Product, Caldolor      
Product Revenues      
Net product revenue 4,132,833 3,112,128 2,721,346
Product, Acetadote, Generic      
Product Revenues      
Net product revenue 4,800,000 4,500,000 5,800,000
Product, Ethyol      
Product Revenues      
Net product revenue 838,386 0 0
Product Sales Related Allowances - Chargebacks, Cash Discounts and Damaged Goods      
Product Revenues      
Accounts receivable, allowances, current 400,000 400,000  
Collaborative Arrangement, Federal Small Business Grant Programs      
Other Revenues      
Other revenues, grants 100,000 200,000 $ 100,000
Outside US | Product, Caldolor      
Product Revenues      
Net product revenue $ 2,000,000 $ 800,000