-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
 MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen
 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 KPcu6nKW24y8ILArz1a4oHwCtep8iuzqS451I0NYU4QwnFloXfaje3iIW3bwxhN+
 se6OouLxDqixNDFeOj2Riw==

<SEC-DOCUMENT>0001047469-99-016489.txt : 19990428
<SEC-HEADER>0001047469-99-016489.hdr.sgml : 19990428
ACCESSION NUMBER:		0001047469-99-016489
CONFORMED SUBMISSION TYPE:	8-K
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	19990421
ITEM INFORMATION:		
FILED AS OF DATE:		19990427

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			VYREX CORP
		CENTRAL INDEX KEY:			0000933972
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				880271109
		STATE OF INCORPORATION:			NV
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		8-K
		SEC ACT:		
		SEC FILE NUMBER:	000-27866
		FILM NUMBER:		99601610

	BUSINESS ADDRESS:	
		STREET 1:		2159 AVENIDA DE LA PLAYA
		CITY:			LA JOLLA
		STATE:			CA
		ZIP:			92037
		BUSINESS PHONE:		6194599522

	MAIL ADDRESS:	
		STREET 1:		2159 AVENIDA DE LA PLAYA
		CITY:			LA JOLLA
		STATE:			CA
		ZIP:			92037
</SEC-HEADER>
<DOCUMENT>
<TYPE>8-K
<SEQUENCE>1
<DESCRIPTION>FORM 8-K
<TEXT>

<PAGE>

                       U.S. SECURITIES AND EXCHANGE COMMISSION
                                 WASHINGTON, DC 20549


                                       FORM 8-K


                           PURSUANT TO SECTION 13 OR 15 (d)
                        OF THE SECURITIES EXCHANGE ACT OF 1934


                                    April 21, 1999


                   Date of Report (Date of earliest event reported)


                                  Vyrex Corporation
                (Exact name of registrant as specified in its charter)


       Nevada                         000-27866                  88-0271109
(State or other jurisdiction         (Commission             (I.R.S. Employer
   of incorporation)                   File No.)             Identification No.)


                 2159 Avenida de la Playa, La Jolla, California 92037
                 (Address of Principal executive offices) (Zip Code)


                                    (619) 454-4446
                 (Registrant's telephone number, including area code)

<PAGE>

                                  VYREX CORPORATION

                                        INDEX

                                                                          PAGE

Item 4.  Changes in Registrant's Certifying Accountant . . . . . . . . . .  3 






                                        2

<PAGE>

                                  VYREX CORPORATION

                ITEM 4.  CHANGES IN REGISTRANT'S CERTIFYING ACCOUNTANT

On or about April 21, 1999, Vyrex Corporation engaged J.H. Cohn, LLP to serve as
independent auditors.  On or about that date, Ernst & Young, LLP was dismissed
as independent auditors of Vyrex Corporation.

Ernst & Young's report on the financial statements for the past two years did
not contain an adverse opinion or a disclaimer of opinion nor was it modified as
to uncertainty, audit scope or accounting principles.

The board of directors of Vyrex Corporation approved the change in independent
auditors.

There were no disagreements with the Company's prior independent auditors, Ernst
& Young, LLP, within the two-year period ended December 31, 1998 and the interim
period of January 1, 1999 through April 21, 1999, on matters of accounting
principles or practices, financial statement disclosure or auditing scope of
procedure.




                                        3

<PAGE>

                                      SIGNATURES

     Pursuant to the requirements of the Securities Exchange Act, the registrant
has duly caused this report to be signed on its behalf by the undersigned,
hereunto duly authorized.

                                        VYREX CORPORATION

DATE: April 27, 1999                    /s/ Martin Malk 
                                        --------------------------------------
                                        Martin Malk as Chief Financial Officer
                                        on Behalf of the Registrant





                                        4
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----
