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Stock-based compensation (Tables)

6 Months Ended

Jun. 30, 2013

Stock-based compensation

Summary of share-based compensation expense

														Period
														from April 5,
		Three Months						Six Months						2011
		Ended,						Ended,						(inception)
		June 30,						June 30,						to June 30,
		2013			2012			2013			2012			2013
Research and development		$	609		$	256		$	1,035		$	493		$	2,447
General and administrative		765			43			1,176			113			1,492

Schedule of assumptions used to estimate fair value of each stock-based option award on the grant date using the Black-Scholes option pricing model

		Three months ended June 30,				Six months ended June 30,
		2013		2012		2013		2012
Volatility		83 - 86%		84 - 87%		83 – 91%		84 - 87%
Risk-free interest rate		1.2 – 1.4%		0.8 - 1.2%		0.9 – 1.4%		0.8 - 1.2%
Dividend yield		—		—		—		—
Expected term		5.3 - 6.1		5.1 - 6.1		5.3 - 6.1		5.1 - 6.1

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- Definition

Tabular disclosure of the allocation of equity-based compensation costs to a given line item on the balance sheet and income statement for the period. This may include the reporting line for the costs and the amount capitalized and expensed.

+ References

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-Publisher FASB

-Name Accounting Standards Codification

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-Name Statement of Financial Accounting Standard (FAS)

-Number 123R

-Paragraph 64

-Subparagraph b

-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.



Reference 3: http://www.xbrl.org/2003/role/presentationRef

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-Publisher FASB

-Name Statement of Financial Accounting Standard (FAS)

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-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.



Reference 5: http://www.xbrl.org/2003/role/presentationRef

-Publisher SEC

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- Definition

Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

-Name Accounting Standards Codification

-Topic 718

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