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Stock-based compensation (Details 2) (USD $)	6 Months Ended	3 Months Ended		6 Months Ended		3 Months Ended		6 Months Ended		3 Months Ended		6 Months Ended		0 Months Ended	3 Months Ended		6 Months Ended	0 Months Ended
	Jun. 30, 2013	Jun. 30, 2013 Stock options	Jun. 30, 2012 Stock options	Jun. 30, 2013 Stock options	Jun. 30, 2012 Stock options	Jun. 30, 2013 Stock options Minimum	Jun. 30, 2012 Stock options Minimum	Jun. 30, 2013 Stock options Minimum	Jun. 30, 2012 Stock options Minimum	Jun. 30, 2013 Stock options Maximum	Jun. 30, 2012 Stock options Maximum	Jun. 30, 2013 Stock options Maximum	Jun. 30, 2012 Stock options Maximum	Dec. 05, 2012 Restricted stock units CEO	Jun. 30, 2013 Restricted stock units CEO	Mar. 31, 2013 Restricted stock units CEO	Jun. 30, 2013 Restricted stock units CEO	Dec. 05, 2012 Time based restricted stock units CEO	Dec. 05, 2012 Performance based restricted stock units CEO
Stock-based compensation
Granted (in shares)		403,880	94,120	841,422	167,275									192,308				128,205	64,103
Vested (in shares)															16,025	16,025	16,025
Weighted average exercise price (in dollars per share)																	$ 0.001
Share Price (in dollars per share)														$ 10.00	$ 10.00		$ 10.00
Weighted average grant date fair value (in dollars per share)		$ 9.90	$ 3.35	$ 9.65	$ 3.15													$ 7.80
Assumptions used to estimate fair value of each stock-based option award on the grant date using the Black-Scholes option pricing model
Volatility (as a percent)						83.00%	84.00%	83.00%	84.00%	86.00%	87.00%	91.00%	87.00%
Risk free interest rate (as a percent)						1.20%	0.80%	0.90%	0.80%	1.40%	1.20%	1.40%	1.20%
Dividend yield (as a percent)						0.00%		0.00%		0.00%		0.00%
Expected term						5 years 3 months 18 days	5 years 1 month 6 days	5 years 3 months 18 days	5 years 1 month 6 days	6 years 1 month 6 days	6 years 1 month 6 days	6 years 1 month 6 days	6 years 1 month 6 days
Additional disclosures
Share-based compensation expense															$ 220,311,000		$ 351,439,000
Granted (in dollars per share)		$ 14.00	$ 4.60	$ 13.37	$ 4.35
Development stage product development revenues	0
Total unrecognized compensation cost, net of estimated forfeitures, related to unvested stock options and restricted stock units (in dollars)	$ 14,200,000
Weighted average period for recognition of compensation cost related to unvested stock options and restricted stock units	3 years

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The number of grants made during the period on other than stock (or unit) option plans (for example, phantom stock or unit plan, stock or unit appreciation rights plan, performance target plan).

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The estimated dividend rate (a percentage of the share price) to be paid (expected dividends) to holders of the underlying shares over the option's term.

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