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v2.4.1.9

Consolidated Statements of Operations and Comprehensive Loss (USD $) In Thousands, except Per Share data, unless otherwise specified | 12 Months Ended
--- | ---
Dec. 31, 2014 | Dec. 31, 2013 | Dec. 31, 2012
Operating expenses: |  |  |
Research and development | $ 21,784 us-gaap_ResearchAndDevelopmentExpense | $ 15,802 us-gaap_ResearchAndDevelopmentExpense | $ 6,323 us-gaap_ResearchAndDevelopmentExpense
Selling, general and administrative | 26,149 us-gaap_SellingGeneralAndAdministrativeExpense | 13,332 us-gaap_SellingGeneralAndAdministrativeExpense | 7,206 us-gaap_SellingGeneralAndAdministrativeExpense
Total operating expenses | 47,933 us-gaap_OperatingExpenses | 29,134 us-gaap_OperatingExpenses | 13,529 us-gaap_OperatingExpenses
Loss from operations | (47,933)us-gaap_OperatingIncomeLoss | (29,134)us-gaap_OperatingIncomeLoss | (13,529)us-gaap_OperatingIncomeLoss
Interest (expense) income, net | (126)us-gaap_InvestmentIncomeInterest | 90 us-gaap_InvestmentIncomeInterest | 19 us-gaap_InvestmentIncomeInterest
Other income (expense), net | 122 us-gaap_OtherNonoperatingIncomeExpense |  |
Loss from equity method investment | (1,583)us-gaap_IncomeLossFromEquityMethodInvestments |  |
Net loss | (49,520)us-gaap_NetIncomeLoss | (29,044)us-gaap_NetIncomeLoss | (13,510)us-gaap_NetIncomeLoss
Net loss per share-basic and diluted (in dollars per share) | $ (2.19)us-gaap_EarningsPerShareBasicAndDiluted | $ (1.80)us-gaap_EarningsPerShareBasicAndDiluted | $ (2.33)us-gaap_EarningsPerShareBasicAndDiluted
Weighted average number of shares used in net loss per share-basic and diluted | 22,647 us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted | 16,160 us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted | 5,810 us-gaap_WeightedAverageNumberOfShareOutstandingBasicAndDiluted
Net loss | (49,520)us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic | (29,044)us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic | (13,510)us-gaap_NetIncomeLossAvailableToCommonStockholdersBasic
Other comprehensive loss: |  |  |
Unrealized gains (losses) on available-for-sale securities | (36)us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax | 16 us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax | (6)us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax
Comprehensive loss | (49,556)us-gaap_ComprehensiveIncomeNetOfTax | (29,028)us-gaap_ComprehensiveIncomeNetOfTax | (13,516)us-gaap_ComprehensiveIncomeNetOfTax
Non-cash stock-based compensation expenses included in operating expenses are as follows: |  |  |
Stock-based compensation expense | 12,407 us-gaap_ShareBasedCompensation | 5,094 us-gaap_ShareBasedCompensation | 1,382 us-gaap_ShareBasedCompensation
Research and development |  |  |
Non-cash stock-based compensation expenses included in operating expenses are as follows: |  |  |
Stock-based compensation expense | 7,578 us-gaap_ShareBasedCompensation / us-gaap_IncomeStatementLocationAxis = us-gaap_ResearchAndDevelopmentExpenseMember | 2,361 us-gaap_ShareBasedCompensation / us-gaap_IncomeStatementLocationAxis = us-gaap_ResearchAndDevelopmentExpenseMember | 1,143 us-gaap_ShareBasedCompensation / us-gaap_IncomeStatementLocationAxis = us-gaap_ResearchAndDevelopmentExpenseMember
Selling, general and administrative |  |  |
Non-cash stock-based compensation expenses included in operating expenses are as follows: |  |  |
Stock-based compensation expense | $ 4,829 us-gaap_ShareBasedCompensation / us-gaap_IncomeStatementLocationAxis = us-gaap_GeneralAndAdministrativeExpenseMember | $ 2,733 us-gaap_ShareBasedCompensation / us-gaap_IncomeStatementLocationAxis = us-gaap_GeneralAndAdministrativeExpenseMember | $ 239 us-gaap_ShareBasedCompensation / us-gaap_IncomeStatementLocationAxis = us-gaap_GeneralAndAdministrativeExpenseMember

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