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Stock-based compensation (Tables)

6 Months Ended

Jun. 30, 2016

Disclosure of Compensation Related Costs, Share-based Payments [Abstract]

Summary of stock option activity and related information

A summary of our stock option activity and related information is as follows:

	Shares			Weighted average exercise price per share				Weighted Average Remaining contractual Term (years)		Aggregate intrinsic value (in thousands)
Outstanding at December 31, 2015	4,650,114			$	21.49			8.58		$	2,970
Granted	1,487,100			7.48
Exercised	(24,663	)		4.52
Forfeited / Canceled	(844,303	)		32.89
Outstanding at June 30, 2016	5,268,248			15.79				8.44		278
Exercisable at June 30, 2016	2,052,413			17.49				7.62		278
Vested and expected to vest at June 30, 2016	4,542,808			15.96				8.37		278

Schedule of assumptions used to estimate fair value of each stock-based option award on the grant date using the Black-Scholes option pricing model

The fair value of each stock-based option award is estimated on the grant date using the Black-Scholes option pricing model using the following assumptions:

	Three months ended June 30,				Six months ended June 30,
	2016		2015		2016		2015
Risk-free interest rate	1.4% - 1.5%		1.6% - 2.3%		1.4% - 2.0%		1.6% - 2.3%
Dividend yield	—		—		—		—
Volatility	86% - 89%		73%		78% - 89%		73% - 75%
Expected term (years)	5.3 - 6.1		5.3 - 9.9		5.3 - 9.9		5.3 - 9.9

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- References

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- Definition

Tabular disclosure of the number and weighted-average exercise prices (or conversion ratios) for share options (or share units) that were outstanding at the beginning and end of the year, vested and expected to vest, exercisable or convertible at the end of the year, and the number of share options or share units that were granted, exercised or converted, forfeited, and expired during the year.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (c)(1)
-URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901

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- Definition

Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (f)(2)
-URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901

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