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Basis of presentation and significant accounting policies (Details) - shares
shares in Thousands
6 Months Ended
Jun. 30, 2016
Jun. 30, 2015
Net loss per share    
Amount excluded from the calculation of diluted net loss per share, prior to the use of the treasury stock method, due to their anti-dilutive effect (in shares) 5,598 4,856
Outstanding stock options and restricted stock units    
Net loss per share    
Amount excluded from the calculation of diluted net loss per share, prior to the use of the treasury stock method, due to their anti-dilutive effect (in shares) 5,598 4,856