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Net Loss Per Share | 12 Months Ended
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Dec. 31, 2017
Earnings Per Share [Abstract] |
Net Loss Per Share | Net Loss Per Share The following table sets forth the computation of basic and diluted loss per share applicable to common stockholders (in thousands, except per share data):
| Year Ended December 31,
| 2017 |  | 2016 |  | 2015
Net loss applicable to common stockholders | $ | (50,975 | ) |  | $ | (82,260 | ) |  | $ | (73,219 | )
Weighted average number of common shares used in net loss per share applicable to common stockholders—basic and diluted | 35,675 |  |  | 32,148 |  |  | 27,085 |
Net loss per share applicable to common stockholders—basic and diluted | $ | (1.43 | ) |  | $ | (2.56 | ) |  | $ | (2.70 | )
The amounts in the table below were excluded from the calculation of diluted net loss per share, prior to the use of the treasury stock method, due to their anti-dilutive effect (in thousands):
| Year Ended December 31,
| 2017 |  | 2016 |  | 2015
Outstanding stock options and restricted stock units | 5,746 |  |  | 4,661 |  |  | 4,751 |

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- Definition The entire disclosure for earnings per share. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 260 -URI http://asc.fasb.org/topic&trid=2144383 + Details
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