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v3.10.0.1

Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands | 3 Months Ended | 6 Months Ended | 12 Months Ended
--- | --- | --- | ---
Jun. 30, 2018 | Jun. 30, 2017 | Jun. 30, 2018 | Jun. 30, 2017 | Dec. 31, 2017 | Dec. 31, 2016
Cash flows from operating activities: |  |  |  |  |  |
Net loss | $ (7,703) | $ (18,186) | $ (15,073) | $ (33,081) | $ (50,975) | $ (82,260)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |  |  |  |
Depreciation and amortization | 200 | 500 | 506 | 951 | 1,650 | 2,238
Impairment of property and equipment related to restructuring |  |  | 2,203 | 250 | 422 | 1,994
Loss on sale of property, plant and equipment |  |  | (34) | 0 | (100) |
Amortization of (discount) premium on debt securities |  |  | (100) | 91 | 59 | 659
Stock-based compensation expense |  |  | 912 | 5,918 | 6,893 | 9,215
Issuance of common stock for director fees |  |  | 55 | 74 | 129 | 154
Net loss on equity method investment | 4 | 454 | 4 | 875 | 1,018 | 1,542
Changes in operating assets and liabilities: |  |  |  |  |  |
Prepaid expenses and other assets |  |  | 996 | (29) | 937 | 946
Accounts payable |  |  | (1,485) | 1,101 | 68 | (1,178)
Accrued expenses, deferred rent and other non-current liabilities |  |  | (1,747) | (3,425) | (5,752) | 4,809
Net cash used in operating activities |  |  | (13,763) | (27,275) | (45,551) | (61,734)
Cash flows from investing activities: |  |  |  |  |  |
Investment in joint venture |  |  | 0 | 0 |  |
Purchases of plant and equipment |  |  | (152) | (101) | (158) | (2,586)
Maturities of short-term investments |  |  | 49,253 | 50,232 | 87,789 | 72,013
Proceeds from sale of property, plant and equipment |  |  | 221 | 0 | 0 | 23,089
Purchases of short-term investments |  |  | (26,662) | (43,476) | (68,857) | (82,671)
Net cash provided by investing activities |  |  | 22,660 | 6,655 | 17,324 | 8,292
Cash flows from financing activities: |  |  |  |  |  |
Net cash provided by financing activities |  |  | 0 | 0 | 0 | 54,148
Net increase (decrease) in cash, cash equivalents and restricted cash |  |  | 8,897 | (20,620) | (28,227) | 706
Cash, cash equivalents and restricted cash at beginning of period |  |  | 16,492 | 44,369 | 44,369 |
Cash, cash equivalents and restricted cash at end of period | 25,390 | 23,749 | 25,390 | 23,749 | 16,492 | 44,369
Restricted Cash and Cash Equivalents [Abstract] |  |  |  |  |  |
Total cash, cash equivalents and restricted cash | $ 25,390 | $ 23,749 | $ 16,492 | $ 23,749 | $ 44,369 | $ 44,369

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