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Commitments and Contingencies - Narrative (Details) $ in Thousands | 1 Months Ended | 12 Months Ended
--- | --- | ---
May 31, 2015 ft² | Dec. 31, 2017 USD ($) | Dec. 31, 2016 USD ($) | Dec. 31, 2015 USD ($)
Operating Leased Assets [Line Items] |  |  |  |
Operating leases, future minimum payments, due in 2018 |  | $ 978 |  |
Operating leases, future minimum payments, due in 2019 |  | 985 |  |
Operating leases, future minimum payments, due in 2020 |  | 924 |  |
Improvement allowance (up to) |  | 1,200 |  |
Rent expense |  | 800 | $ 800 | $ 900
Office and laboratory |  |  |  |
Operating Leased Assets [Line Items] |  |  |  |
Square footage of office and laboratory space (in square feet) | ft² | 25,200 |  |  |
Optional extension, term | 5 years |  |  |
Operating leases, future minimum payments, due in 2018 |  | 1,000 |  |
Operating leases, future minimum payments, due in 2019 |  | 1,000 |  |
Operating leases, future minimum payments, due in 2020 |  | 900 |  |
Security deposit |  | $ 400 |  |

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- Definition Amount of required minimum rental payments for operating leases having an initial or remaining non-cancelable lease term in excess of one year due in the next fiscal year following the latest fiscal year. Excludes interim and annual periods when interim periods are reported on a rolling approach, from latest balance sheet date. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 840 -SubTopic 10 -Section 55 -Paragraph 40 -Subparagraph (Note 3) -URI http://asc.fasb.org/extlink&oid=82846649&loc=d3e38371-112697 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 840 -SubTopic 20 -Section 50 -Paragraph 2 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=77902758&loc=d3e41502-112717 + Details
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