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v3.10.0.1

Consolidated Statements of Stockholders' Equity - USD ($) $ in Thousands | Total | Common stock | Additional paid-in capital | Accumulated other comprehensive gain (loss) | Accumulated deficit
--- | --- | --- | --- | --- | ---
Beginning balance (in shares) at Dec. 31, 2014 |  | 24,084,637 |  |  |
Beginning balance at Dec. 31, 2014 | $ 55,325 | $ 24 | $ 150,025 | $ (26) | $ (94,698)
Increase (decrease) in Stockholders' Equity |  |  |  |  |
Issuance of common stock under public offering, net of underwriters' discounts and issuance costs (in shares) |  | 2,645,000 |  |  |
Issuance of common stock under public offering, net of underwriters' discounts and issuance costs | 124,063 | $ 3 | 124,060 |  |
Vesting of Founders Stock (in shares) |  | 329,021 |  |  |
Issuance of common stock to board of directors & CEO (in shares) |  | 15,808 |  |  |
Issuance of common stock to board of directors | 165 |  | 165 |  |
Exercise of stock options (in shares) |  | 208,734 |  |  |
Exercise of stock options | 1,440 |  | 1,440 |  |
Stock-based compensation expense | 19,337 |  | 19,337 |  |
Vesting of restricted stock (in shares) |  | 13,547 |  |  |
Vesting of restricted stock | (117) |  | (117) |  |
Unrealized gain (loss) on investments | (144) |  |  | (144) |
Net loss | (73,219) |  |  |  | (73,219)
Ending balance (in shares) at Dec. 31, 2015 |  | 27,296,747 |  |  |
Ending balance at Dec. 31, 2015 | 126,850 | $ 27 | 294,910 | (170) | (167,917)
Increase (decrease) in Stockholders' Equity |  |  |  |  |
Issuance of common stock under public offering, net of underwriters' discounts and issuance costs (in shares) |  | 8,222,500 |  |  |
Issuance of common stock under public offering, net of underwriters' discounts and issuance costs | 53,925 | $ 9 | 53,916 |  |
Issuance of common stock to board of directors & CEO (in shares) |  | 42,047 |  |  |
Issuance of common stock to board of directors | 154 |  | 154 |  |
Exercise of stock options (in shares) |  | 63,961 |  |  |
Exercise of stock options | 224 |  | 224 |  |
Stock-based compensation expense | 9,215 |  | 9,215 |  |
Vesting of restricted stock (in shares) |  | 16,250 |  |  |
Unrealized gain (loss) on investments | 110 |  |  | 110 |
Net loss | (82,260) |  |  |  | (82,260)
Ending balance (in shares) at Dec. 31, 2016 |  | 35,641,505 |  |  |
Ending balance at Dec. 31, 2016 | 108,218 | $ 36 | 358,419 | (60) | (250,177)
Increase (decrease) in Stockholders' Equity |  |  |  |  |
Issuance of common stock to board of directors & CEO (in shares) |  | 83,725 |  |  |
Issuance of common stock to board of directors | 129 |  | 129 |  |
Stock-based compensation expense | 6,893 |  | 6,893 |  |
Unrealized gain (loss) on investments | 33 |  |  | 33 |
Adjustment to beginning accumulated deficit and additional paid-in capital resulting from the adoption of ASU 2016-09 | Accounting Standards Update 2016-09 |  |  | 328 |  | (328)
Net loss | (50,975) |  |  |  | (50,975)
Ending balance (in shares) at Dec. 31, 2017 |  | 35,725,230 |  |  |
Ending balance at Dec. 31, 2017 | 64,298 | $ 36 | $ 365,769 | $ (27) | $ (301,480)
Increase (decrease) in Stockholders' Equity |  |  |  |  |
Net loss | (15,073) |  |  |  |
Ending balance at Jun. 30, 2018 | $ 50,210 |  |  |  |

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