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v3.10.0.1

Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
Cash flows from operating activities: |  |  |
Net loss | $ (50,975) | $ (82,260) | $ (73,219)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Depreciation and amortization | 1,650 | 2,238 | 1,286
Impairment of property and equipment | 0 | 147 | 0
Impairment of property and equipment related to restructuring | 422 | 1,994 | 0
Amortization of premium on debt securities | 59 | 659 | 1,116
Stock-based compensation expense | 6,893 | 9,215 | 19,337
Issuance of common stock for board of directors fees | 129 | 154 | 165
Net loss on equity method investment | 1,018 | 1,542 | 1,561
Changes in operating assets and liabilities: |  |  |
Prepaid expenses and other assets | 937 | 946 | (1,113)
Accounts payable | 68 | (1,178) | (171)
Accrued expenses, current and other non-current liabilities | (5,752) | 4,809 | 752
Net cash used in operating activities | (45,551) | (61,734) | (50,286)
Cash flows from investing activities: |  |  |
Investment in joint venture | (1,100) | (1,750) | (1,500)
Purchases of property and equipment | (158) | (2,586) | (5,229)
Maturities of short-term investments | 87,789 | 72,013 | 53,528
Sales of short-term investments | 0 | 23,089 | 10,817
Purchases of short-term investments | (68,857) | (82,671) | (95,225)
(Decrease) increase in restricted cash | (350) | 197 | (681)
Net cash provided by investing activities | 17,324 | 8,292 | (38,290)
Cash flows from financing activities: |  |  |
Net proceeds from the issuance of common stock | 0 | 53,925 | 124,063
Issuances of common stock under benefit plans, net of withholding taxes paid | 0 | 223 | 1,323
Net cash provided by financing activities | 0 | 54,148 | 125,386
Net increase (decrease) in cash, cash equivalents and restricted cash | (28,227) | 706 | 36,810
Cash and cash equivalents at beginning of period | 43,930 | 43,224 | 6,414
Cash and cash equivalents at end of period | 15,703 | 43,930 | 43,224
Supplemental disclosure of non-cash investing activity |  |  |
Additions of property and equipment included in accounts payable and accrued liabilities | $ 25 | $ 55 | $ 1,003

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