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Property and equipment (Details) - USD ($)
 1 Months Ended 3 Months Ended 6 Months Ended 12 Months Ended
Feb. 28, 2018
Jul. 31, 2017
Jun. 30, 2018
Jun. 30, 2017
Jun. 30, 2018
Jun. 30, 2017
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Jan. 31, 2017
Property and equipment                    
Total property and equipment, gross     $ 2,263,000   $ 2,263,000   $ 6,813,000 $ 9,000,000    
Less: accumulated depreciation and amortization     (1,860,000)   (1,860,000)   (3,700,000) (3,428,000)    
Total property and equipment, net     403,000   403,000   3,113,000 5,572,000    
Depreciation and amortization expense     200,000 $ 500,000 506,000 $ 951,000 1,650,000 2,238,000 $ 1,286,000  
Fixed assets held-for-sale $ 300,000           300,000     $ 500,000
Carrying value of assets sold   $ 200,000                
Proceeds from sale of property held-for-sale $ 200,000 300,000                
Loss on sale of property, plant and equipment   $ 100,000     34,000 $ 0 100,000      
Tangible asset impairment charges         2,200,000   400,000 2,000,000 $ 0  
Assets held-for-sale, not part of disposal group     100,000   100,000          
Laboratory equipment                    
Property and equipment                    
Total property and equipment, gross     1,732,000   1,732,000   3,480,000 5,184,000    
Furniture                    
Property and equipment                    
Total property and equipment, gross     230,000   230,000   371,000 793,000    
Computer equipment                    
Property and equipment                    
Total property and equipment, gross     13,000   13,000   208,000 208,000    
Leasehold improvements                    
Property and equipment                    
Total property and equipment, gross     $ 288,000   $ 288,000   $ 2,754,000 $ 2,815,000