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(Details) - USD ($)
$ in Thousands
Jun. 30, 2018
Dec. 31, 2017
Dec. 31, 2016
Payables and Accruals [Abstract]      
Compensation and related benefits, including severance $ 1,571 $ 2,215 $ 5,869
Development, site costs and contract manufacturing 675 519 524
Legal, audit and tax services 1,104 1,542 1,280
Consulting 59 160 888
Other accrued expenses and other current liabilities 581 1,126  
Accrued liabilities $ 3,990 $ 5,562 $ 11,026