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Consolidated Statements of Stockholders' Equity - USD ($)
$ in Thousands
Total
Common stock
Additional paid-in capital
Accumulated other comprehensive gain (loss)
Accumulated deficit
Beginning balance (in shares) at Dec. 31, 2014   24,084,637      
Beginning balance at Dec. 31, 2014 $ 55,325 $ 24 $ 150,025 $ (26) $ (94,698)
Increase (decrease) in Stockholders' Equity          
Issuance of common stock under public offering, net of underwriters' discounts and issuance costs (in shares)   2,645,000      
Issuance of common stock under public offering, net of underwriters' discounts and issuance costs 124,063 $ 3 124,060    
Vesting of Founders Stock (in shares)   329,021      
Issuance of common stock to board of directors & CEO (in shares)   15,808      
Issuance of common stock to board of directors 165   165    
Exercise of stock options (in shares)   208,734      
Exercise of stock options 1,440   1,440    
Stock-based compensation expense 19,337   19,337    
Vesting of restricted stock (in shares)   13,547      
Vesting of restricted stock (117)   (117)    
Unrealized gain (loss) on investments (144)     (144)  
Net loss (73,219)       (73,219)
Ending balance (in shares) at Dec. 31, 2015   27,296,747      
Ending balance at Dec. 31, 2015 126,850 $ 27 294,910 (170) (167,917)
Increase (decrease) in Stockholders' Equity          
Issuance of common stock under public offering, net of underwriters' discounts and issuance costs (in shares)   8,222,500      
Issuance of common stock under public offering, net of underwriters' discounts and issuance costs 53,925 $ 9 53,916    
Issuance of common stock to board of directors & CEO (in shares)   42,047      
Issuance of common stock to board of directors 154   154    
Exercise of stock options (in shares)   63,961      
Exercise of stock options 224   224    
Stock-based compensation expense 9,215   9,215    
Vesting of restricted stock (in shares)   16,250      
Unrealized gain (loss) on investments 110     110  
Net loss (82,260)       (82,260)
Ending balance (in shares) at Dec. 31, 2016   35,641,505      
Ending balance at Dec. 31, 2016 108,218 $ 36 358,419 (60) (250,177)
Increase (decrease) in Stockholders' Equity          
Issuance of common stock to board of directors & CEO (in shares)   83,725      
Issuance of common stock to board of directors 129   129    
Stock-based compensation expense 6,893   6,893    
Unrealized gain (loss) on investments 33     33  
Adjustment to beginning accumulated deficit and additional paid-in capital resulting from the adoption of ASU 2016-09 | Accounting Standards Update 2016-09     328   (328)
Net loss (50,975)       (50,975)
Ending balance (in shares) at Dec. 31, 2017   35,725,230      
Ending balance at Dec. 31, 2017 64,298 $ 36 $ 365,769 $ (27) $ (301,480)
Increase (decrease) in Stockholders' Equity          
Net loss (15,073)        
Ending balance at Jun. 30, 2018 $ 50,210