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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
 3 Months Ended 6 Months Ended 12 Months Ended
Jun. 30, 2018
Jun. 30, 2017
Jun. 30, 2018
Jun. 30, 2017
Dec. 31, 2017
Dec. 31, 2016
Cash flows from operating activities:            
Net loss $ (7,703) $ (18,186) $ (15,073) $ (33,081) $ (50,975) $ (82,260)
Adjustments to reconcile net loss to net cash used in operating activities:            
Depreciation and amortization 200 500 506 951 1,650 2,238
Impairment of property and equipment related to restructuring     2,203 250 422 1,994
Loss on sale of property, plant and equipment     (34) 0 (100)  
Amortization of (discount) premium on debt securities     (100) 91 59 659
Stock-based compensation expense     912 5,918 6,893 9,215
Issuance of common stock for director fees     55 74 129 154
Net loss on equity method investment 4 454 4 875 1,018 1,542
Changes in operating assets and liabilities:            
Prepaid expenses and other assets     996 (29) 937 946
Accounts payable     (1,485) 1,101 68 (1,178)
Accrued expenses, deferred rent and other non-current liabilities     (1,747) (3,425) (5,752) 4,809
Net cash used in operating activities     (13,763) (27,275) (45,551) (61,734)
Cash flows from investing activities:            
Investment in joint venture     0 0    
Purchases of plant and equipment     (152) (101) (158) (2,586)
Maturities of short-term investments     49,253 50,232 87,789 72,013
Proceeds from sale of property, plant and equipment     221 0 0 23,089
Purchases of short-term investments     (26,662) (43,476) (68,857) (82,671)
Net cash provided by investing activities     22,660 6,655 17,324 8,292
Cash flows from financing activities:            
Net cash provided by financing activities     0 0 0 54,148
Net increase (decrease) in cash, cash equivalents and restricted cash     8,897 (20,620) (28,227) 706
Cash, cash equivalents and restricted cash at beginning of period     16,492 44,369 44,369  
Cash, cash equivalents and restricted cash at end of period 25,390 23,749 25,390 23,749 16,492 44,369
Restricted Cash and Cash Equivalents [Abstract]            
Total cash, cash equivalents and restricted cash $ 25,390 $ 23,749 $ 16,492 $ 23,749 $ 44,369 $ 44,369