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Income Taxes (Tables)

12 Months Ended

Dec. 31, 2017

Income Tax Disclosure [Abstract]

Schedule of Income Tax Expense

The expense for income taxes consists of the following (in thousands):

	Year Ended Year ended December 31,
	2017				2016				2015
Current:
Federal	$	—			$	—			$	—
State	11				18				21
Foreign	56				183				54
Total income tax expense	67				201				75

Schedule of reconciliation of income taxes computed using the U.S. federal statutory rate to that reflected in operations

A reconciliation of income taxes computed using the U.S. federal statutory rate to that reflected in operations follows:

	Year Ended Year ended December 31,
	2017			2016			2015
Income tax benefit using U.S. federal statutory rate	34.00	%		34.00	%		34.00	%
State income taxes, net of federal benefit	5.08	%		4.86	%		5.23	%
Research and development tax credits	1.51	%		0.90	%		0.83	%
Permanent items - stock based compensation	(7.60	)%		(2.66	)%		(8.15	)%
Foreign differential	(11.67	)%		(11.03	)%		(14.25	)%
Other adjustments	(0.52	)%		(0.11	)%		(0.94	)%
Impact of Tax Reform	(39.42	)%		—	%		—	%
Change in the valuation allowance	18.49	%		(26.21	)%		(16.82	)%
	(0.13	)%		(0.25	)%		(0.10	)%

Schedule of principal components of deferred tax assets

The principal components of our deferred tax assets are as follows (in thousands):

	2017			2016
Deferred Tax Assets:
Net operating loss carryforwards	53,228			53,654
Tax credit carryforwards	3,944			3,034
Accrued expenses	687			1,737
Stock based compensation	4,591			7,750
Intangibles	2,240			3,366
Other	903			1,181
Gross deferred tax assets	65,593			70,722
Valuation allowance	(65,593	)		(70,722	)
Net deferred tax assets	—			—

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- References

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- Definition

Tabular disclosure of the components of income tax expense attributable to continuing operations for each year presented including, but not limited to: current tax expense (benefit), deferred tax expense (benefit), investment tax credits, government grants, the benefits of operating loss carryforwards, tax expense that results from allocating certain tax benefits either directly to contributed capital or to reduce goodwill or other noncurrent intangible assets of an acquired entity, adjustments of a deferred tax liability or asset for enacted changes in tax laws or rates or a change in the tax status of the entity, and adjustments of the beginning-of-the-year balances of a valuation allowance because of a change in circumstances that causes a change in judgment about the realizability of the related deferred tax asset in future years.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 9
-URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32639-109319

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- Definition

Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 2
-URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32537-109319

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- Definition

Tabular disclosure of the reconciliation using percentage or dollar amounts of the reported amount of income tax expense attributable to continuing operations for the year to the amount of income tax expense that would result from applying domestic federal statutory tax rates to pretax income from continuing operations.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 12
-URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32687-109319

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