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Net Loss Per Share (Tables)
 6 Months Ended 12 Months Ended
Jun. 30, 2018
Dec. 31, 2017
Earnings Per Share [Abstract]    
Schedule of computation of basic and diluted loss per share applicable to common stockholders  
The following table sets forth the computation of basic and diluted loss per share applicable to common stockholders (in thousands, except per share data):
 
Year Ended December 31,
 
2017
 
2016
 
2015
Net loss applicable to common stockholders
$
(50,975
)
 
$
(82,260
)
 
$
(73,219
)
Weighted average number of common shares used in net loss per share applicable to common stockholders—basic and diluted
35,675

 
32,148

 
27,085

Net loss per share applicable to common stockholders—basic and diluted
$
(1.43
)
 
$
(2.56
)
 
$
(2.70
)
Schedule of amounts excluded from the calculation of diluted net loss per share, prior to the use of the treasury stock method, due to their anti-dilutive effect
The amounts in the table below were excluded from the calculation of diluted net loss per share due to their anti-dilutive effect (in thousands):
 
As of June 30,
 
2018
 
2017
Outstanding stock options and restricted stock units
5,396

 
7,469
The amounts in the table below were excluded from the calculation of diluted net loss per share, prior to the use of the treasury stock method, due to their anti-dilutive effect (in thousands):
 
Year Ended December 31,
 
2017
 
2016
 
2015
Outstanding stock options and restricted stock units
5,746

 
4,661

 
4,751