<SEC-DOCUMENT>0001567619-22-000944.txt : 20220110
<SEC-HEADER>0001567619-22-000944.hdr.sgml : 20220110
<ACCEPTANCE-DATETIME>20220110171558
ACCESSION NUMBER:		0001567619-22-000944
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20211230
FILED AS OF DATE:		20220110
DATE AS OF CHANGE:		20220110

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Rock Springs Capital Management LP
		CENTRAL INDEX KEY:			0001595725
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-35890
		FILM NUMBER:		22522021

	BUSINESS ADDRESS:	
		STREET 1:		650 SOUTH EXETER STREET
		STREET 2:		SUITE 1070
		CITY:			BALTIMORE
		STATE:			MD
		ZIP:			21202
		BUSINESS PHONE:		4102200129

	MAIL ADDRESS:	
		STREET 1:		650 SOUTH EXETER STREET
		STREET 2:		SUITE 1070
		CITY:			BALTIMORE
		STATE:			MD
		ZIP:			21202

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Rock Springs Capital LLC
		CENTRAL INDEX KEY:			0001735397
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-35890
		FILM NUMBER:		22522020

	BUSINESS ADDRESS:	
		STREET 1:		650 SOUTH EXETER STREET
		STREET 2:		SUITE 1070
		CITY:			BALTIMORE
		STATE:			MD
		ZIP:			21202
		BUSINESS PHONE:		410-220-0142

	MAIL ADDRESS:	
		STREET 1:		650 SOUTH EXETER STREET
		STREET 2:		SUITE 1070
		CITY:			BALTIMORE
		STATE:			MD
		ZIP:			21202

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Rock Springs Capital Master Fund LP
		CENTRAL INDEX KEY:			0001735393
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-35890
		FILM NUMBER:		22522019

	BUSINESS ADDRESS:	
		STREET 1:		650 SOUTH EXETER STREET
		STREET 2:		SUITE 1070
		CITY:			BALTIMORE
		STATE:			MD
		ZIP:			21202
		BUSINESS PHONE:		410-220-0142

	MAIL ADDRESS:	
		STREET 1:		190 ELGIN AVENUE
		CITY:			GEORGE TOWN
		STATE:			E9
		ZIP:			KY1 9001

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Tempest Therapeutics, Inc.
		CENTRAL INDEX KEY:			0001544227
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				451472564
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		7000 SHORELINE COURT
		STREET 2:		SUITE 275
		CITY:			SOUTH SAN FRANCISCO
		STATE:			CA
		ZIP:			94080
		BUSINESS PHONE:		415-798-8589

	MAIL ADDRESS:	
		STREET 1:		7000 SHORELINE COURT
		STREET 2:		SUITE 275
		CITY:			SOUTH SAN FRANCISCO
		STATE:			CA
		ZIP:			94080

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Millendo Therapeutics, Inc.
		DATE OF NAME CHANGE:	20181207

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	OvaScience, Inc.
		DATE OF NAME CHANGE:	20120308
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>doc1.xml
<DESCRIPTION>FORM 3
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2021-12-30</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001544227</issuerCik>
        <issuerName>Tempest Therapeutics, Inc.</issuerName>
        <issuerTradingSymbol>TPST</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001595725</rptOwnerCik>
            <rptOwnerName>Rock Springs Capital Management LP</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>650 SOUTH EXETER STREET</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 1070</rptOwnerStreet2>
            <rptOwnerCity>BALTIMORE</rptOwnerCity>
            <rptOwnerState>MD</rptOwnerState>
            <rptOwnerZipCode>21202</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001735397</rptOwnerCik>
            <rptOwnerName>Rock Springs Capital LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>650 SOUTH EXETER STREET</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 1070</rptOwnerStreet2>
            <rptOwnerCity>BALTIMORE</rptOwnerCity>
            <rptOwnerState>MD</rptOwnerState>
            <rptOwnerZipCode>21202</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001735393</rptOwnerCik>
            <rptOwnerName>Rock Springs Capital Master Fund LP</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>650 SOUTH EXETER STREET</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 1070</rptOwnerStreet2>
            <rptOwnerCity>BALTIMORE</rptOwnerCity>
            <rptOwnerState>MD</rptOwnerState>
            <rptOwnerZipCode>21202</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>750000</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See footnote</value>
                    <footnoteId id="F1"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>73654</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See footnote</value>
                    <footnoteId id="F2"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes>
        <footnote id="F1">The securities reported herein are held of record by Rock Springs Capital Master Fund LP (&quot;Master Fund&quot;). Rock Springs Capital LLC (&quot;RSC&quot;) is the general partner of Rock Springs Capital Management LP (&quot;RSCM&quot;) which is the investment manager to Master Fund. RSC and RSCM may therefore be deemed to have or share beneficial ownership of the Common Stock held directly by Master Fund.</footnote>
        <footnote id="F2">The securities reported herein are held of record by Four Pines Master Fund LP (&quot;Four Pines&quot;). RSC is the general partner of RSCM which is the investment manager to Four Pines. RSC and RSCM may therefore be deemed to have or share beneficial ownership of the Common Stock held directly by Four Pines.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>By: /s/ Mark Bussard, Authorized Signatory, Rock Springs Capital Management LP</signatureName>
        <signatureDate>2022-01-10</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>By: /s/ Mark Bussard, Authorized Signatory, Rock Springs Capital LLC</signatureName>
        <signatureDate>2022-01-10</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>By: /s/ Mark Bussard, Authorized Signatory, Rock Springs Capital Master Fund LP</signatureName>
        <signatureDate>2022-01-10</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
