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Stock-Based Compensation (Tables) | 12 Months Ended
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Dec. 31, 2025
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |
Summary of Stock Options | The following shows the stock option activities for the years ended December 31, 2025 and 2024:
|  |  |  | Total Options Outstanding |  |  | Weighted-Average Exercise Price |
Balance—December 31, 2023 |  |  |  |  | 273,393 |  |  | $ | 94.64 |
Granted |  |  |  |  | 69,009 |  |  |  | 51.48 |
Exercised |  |  |  |  | (6,284 | ) |  |  | 24.83 |
Cancelled and forfeited |  |  |  |  | (16,028 | ) |  |  | 106.99 |
Balance—December 31, 2024 |  |  |  |  | 320,090 |  |  | $ | 86.06 |
Granted |  |  |  |  | 130,014 |  |  |  | 11.20 |
Exercised |  |  |  |  | — |  |  |  | — |
Cancelled and forfeited |  |  |  |  | — |  |  |  | — |
Balance—December 31, 2025 |  |  |  |  | 450,104 |  |  |  | 64.44 |
Summary of Information About Stock Options Outstanding | The following table summarizes information about stock options outstanding at December 31, 2025:
|  | Shares |  |  | Weighted Average Remaining Contractual Life (In Years) |  |  | Weighted Average Exercise Price |  |  | Aggregate Intrinsic Value |
Options outstanding |  |  | 450,104 |  |  |  | 7.71 |  |  | $ | 64.44 |  |  | $ | — |
Vested and expected to vest |  |  | 450,104 |  |  |  | 7.71 |  |  | $ | 64.44 |  |  | $ | — |
Exercisable |  |  | 441,792 |  |  |  | 7.70 |  |  | $ | 64.51 |  |  | $ | — |
Schedule of Stock Based Compensation Expense | Company’s consolidated statements of operations for the years ended December 31, 2025 and 2024:
|  | 2025 |  |  | 2024 |
Research and development |  | $ | 1,179 |  |  | $ | 2,222 |
General and administrative |  |  | 1,939 |  |  |  | 3,081 |
Total |  | $ | 3,118 |  |  | $ | 5,303 |
Share-based Payment Arrangement, Employee |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |
Summary of Grant Date Fair Value | The fair value of employee stock options was estimated using the following assumptions for the years ended December 31, 2025 and 2024:
|  | 2025 |  |  | 2024 |
Expected term (in years) |  | 6.0 |  |  | 5.5 - 6.1 |
Expected volatility |  | 115% - 116% |  |  | 109% - 124% |
Risk-free interest rate |  |  | 4.4 | % |  | 3.5% - 4.7% |
Dividends |  |  | — | % |  |  | — | %

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- Definition Tabular disclosure of number, weighted-average exercise price or conversion ratio, aggregate intrinsic value, and weighted-average remaining contractual term for outstanding options that are fully vested and expected to vest. Includes, but is not limited to, unvested options for which requisite service period has not been rendered but that are expected to vest based on achievement of performance condition, if forfeitures are recognized when they occur. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 718 -SubTopic 10 -Subparagraph (e)(1) -Name Accounting Standards Codification -Paragraph 2 -Section 50 -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 + Details
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- Definition Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 718 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (c)(1) -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (d) -SubTopic 10 -Topic 718 -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (e) -SubTopic 10 -Topic 718 -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 + Details
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- Definition Line items represent financial concepts included in a table. 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