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Accrued Expenses (Tables) | 6 Months Ended | 12 Months Ended
--- | --- | ---
Jun. 30, 2018 | Dec. 31, 2017
Accrued Expenses [Abstract] |  |
Schedule of accrued expenses |
|  | June 30, 2018 |  |  | December 31, 2017 |
Accrued licensing agreement fees |  | $ | 65,000 |  |  | $ | 120,000 |
Accrued services (1) |  |  | 1,118,872 |  |  |  | 600,339 |
Accrued issuance costs |  |  | 30,933 |  |  |  | 28,083 |
Accrued payroll |  |  | 256,926 |  |  |  | 223,195 |
Advances |  |  | — |  |  |  | 50,000 |
Other (2) |  |  | 6,947 |  |  |  | — |
|  | $ | 1,478,678 |  |  | $ | 1,021,617 |
(1) | The accrued services related to legal and other service costs in the amount of $1,029,069 and $89,803 as of June 30, 2018, respectively, and $553,037 and $47,302 as of December 31, 2017, respectively. Legal costs in 2017 were largely associated with the Acquisition, and legal costs in 2018 related largely to the issuance of our convertible notes and other securities matters.
(2) | Accrued expenses include an obligation to issue stock options to a consultant that has met vesting requirements as of June 30, 2018 in the amount of $6,947. See Note 10 – Stock-Based Compensation for further detail.
|  | 2017 |  |  | 2016 |
Accrued license fees |  | $ | 120,000 |  |  | $ | 182,009 |
Accrued services |  |  | 600,339 | (1) |  |  | 31,186 |
Accrued issuance costs |  |  | 28,083 |  |  |  | 22,015 |
Accrued payroll |  |  | 223,195 |  |  |  | 28,252 |
Advances |  |  | 50,000 |  |  |  | — |
Other |  |  | — |  |  |  | 881 |
|  | $ | 1,021,617 |  |  | $ | 264,343 |
(1) The 2017 accrued services related to legal and other service costs in the amount of $553,037 and $47,302, respectively, largely related to costs associated with the Acquisition.

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