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Accrued Expenses (Details) - USD ($) | Jun. 30, 2018 | Dec. 31, 2017 | Dec. 31, 2016
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Schedule of Accrued Expenses [Abstract] |  |  |  |  |
Accrued licensing agreement fees | $ 65,000 |  | $ 120,000 |  | $ 182,009
Accrued services | 1,118,872 | [1] | 600,339 | [1],[2] | 31,186
Accrued issuance costs | 30,933 |  | 28,083 |  | 22,015
Accrued payroll | 256,926 |  | 223,195 |  | 28,252
Advances |  |  | 50,000 |  |
Other | 6,947 | [3] |  | [3] | 881
Total accrued expenses | $ 1,478,678 |  | $ 1,021,617 |  | $ 264,343
[1] | The accrued services related to legal and other service costs in the amount of $1,029,069 and $89,803 as of June 30, 2018, respectively, and $553,037 and $47,302 as of December 31, 2017, respectively. Legal costs in 2017 were largely associated with the Acquisition, and legal costs in 2018 related largely to the issuance of our convertible notes and other securities matters.
[2] | The 2017 accrued services related to legal and other service costs in the amount of $553,037 and $47,302, respectively, largely related to costs associated with the Acquisition.
[3] | Accrued expenses include an obligation to issue stock options to a consultant that has met vesting requirements as of June 30, 2018 in the amount of $6,947. See Note 10 - Stock-Based Compensation for further detail.

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- Definition Carrying value as of the balance sheet date of obligations incurred and payable, pertaining to costs that are statutory in nature, are incurred on contractual obligations, or accumulate over time and for which invoices have not yet been received or will not be rendered. Examples include taxes, interest, rent and utilities. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer). + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02.20) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 + Details
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